1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste: Proportion developing new caries
1000 to 1250 ppm F toothpaste showed no clear difference in proportion developing new caries compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 12 to 60 months 1000 to 1250 ppm F toothpaste showed no clear difference in proportion developing new caries compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty). Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane All outcomes | RR 0.9 [0.77, 1.06] | 7 studies · 1898 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes | 2018-08 | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.