Same question across reviews · CL0151

intervention :: Fluoride toothpaste/dentifrice -> Caries incidence/onset

ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.

Reviews

Questions

current versions

GRADE rated

Review overlap (CCA)

over all included studies of these reviews, not this question only

Question	Effect	Evidence	Status / GRADE
1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.86 [0.74, 0.99]	1 study · 905 participants	Low
1450 ppm F toothpaste vs 440 ppm F toothpaste Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · 60 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.87 [0.81, 0.94]	1 study · 2362 participants	Moderate
1000 or 1100 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Adults with mature permanent dentition (aged 18 to 93 years at study start) Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	Proportion of adults developing new caries: no studies reported this outcome.	0 studies	No studies
1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 12 to 60 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.9 [0.77, 1.06]	7 studies · 1898 participants	Low
1450 to 1500 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 1.02 [0.93, 1.11]	2 studies · 4328 participants	Low
1450 to 1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.95 [0.91, 0.98]	1 study · 945 participants	Low
1450 ppm F toothpaste vs 250 ppm F toothpaste Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · 22 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 0.92 [0.54, 1.57]	1 study · 172 participants	Low
250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 24 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane	RR 1.07 [0.91, 1.27]	2 studies · 684 participants	Low
Fluoride toothpaste vs Fluoride mouthrinse Proportion of children developing new caries (permanent) · Children or adolescents aged 16 or less at the start of the study One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing… (2004) · Cochrane	RR 0.90 [0.60, 1.37]	1 study	Ungraded
Fluoride toothpaste vs Placebo (non-fluoride) toothpaste Proportion of children developing one or more new caries · Children and adolescents aged 16 years or less · At least 1 year Fluoride toothpastes for preventing dental caries in children and adolescents (2003) · Cochrane	RR 0.91 [0.80, 1.04]	7 studies · 2878 participants	Ungraded

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