Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,268 questions · 1,343 findings · 197 reviews

No studies found 317 · 23.6%GRADE not reported 189 · 14.1%Very low 356 · 26.5%Low 271 · 20.2%Moderate 173 · 12.9%High 37 · 2.8%

Laparoscopic myomectomy vs open myomectomy (all types)

Perioperative in‐hospital adverse events; unscheduled return to theatre · women with uterine fibroids

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; unscheduled return to… compared with open myomectomy (all types) (low certainty).

1 finding from 1 review

Laparoscopic myomectomy vs open myomectomy (all types)

Perioperative in‐hospital adverse events; laparoconversion · women with uterine fibroids

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; laparoconversion compared with open myomectomy (all types) (moderate certainty).

1 finding from 1 review

Laparoscopic myomectomy vs open myomectomy (all types)

Perioperative in‐hospital adverse events; injury to pelvic organs · women with uterine fibroids

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; injury to pelvic organs compared with open myomectomy (all types) (moderate certainty).

1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Reduction of snoring · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Position of the incisors (upper incisor inclination) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    The author reported that data (1.NA, 1-NA, 1-PP, 1.NB, 1-NB, 1-GoMe) showed a statistically significant difference. There was palatal inclination of the upper incisors in the intervention group that contributed to…
    1 study
    GRADE not reported

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Side effects / tolerability · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

All cause mortality · people with cancer who have febrile neutropenia

beta‐lactam monotherapy showed no clear difference in all cause mortality compared with beta‐lactam‐aminoglycoside combination therapy (high certainty).

1 finding from 1 review

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Any nephrotoxicity ‐ Ag dosing regimen (Copy) · people with cancer who have febrile neutropenia

beta‐lactam monotherapy leads to lower any nephrotoxicity ‐ Ag dosing regimen (Copy) compared with beta‐lactam‐aminoglycoside combination therapy (high certainty).

1 finding from 1 review

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Clinical failure—same beta lactam Antibiotic modifications · people with cancer who have febrile neutropenia

beta‐lactam monotherapy probably leads to higher treatment failure ‐ same beta‐lactam compared with beta‐lactam‐aminoglycoside combination therapy (moderate certainty).

1 finding from 1 review

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Treatment failure ‐ different beta‐lactam · people with cancer who have febrile neutropenia

beta‐lactam monotherapy may leads to lower treatment failure ‐ different beta‐lactam compared with beta‐lactam‐aminoglycoside combination therapy (low certainty).

1 finding from 1 review