Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,268 questions · 1,343 findings · 197 reviews

No studies found 317 · 23.6%GRADE not reported 189 · 14.1%Very low 356 · 26.5%Low 271 · 20.2%Moderate 173 · 12.9%High 37 · 2.8%

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Mandibular ramus growth · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Reduction or treatment of obstructive sleep apnoea syndrome (OSAS) or upper airway resistance syndrome (UARS) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Mandibular ramus growth · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    Cephalometric data (SNA, Co-A, SNB, Ar-Go, Ar.GoMe, Co-Gn, ANB) were reported to be not significantly different between groups; effects were dento-alveolar rather than skeletal. No pooled estimate (Almeida 2005).
    1 study
    GRADE not reported

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Alteration of hyperdivergent growth pattern · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    The angles (SN.GoGN, SN.PP, NS.Gn) and linear measures (AFA, AFP, AFAI) did not demonstrate significant alterations between groups; interventions did not produce significant changes in the skeletal maxillary or…
    1 study
    GRADE not reported

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Expansion of the upper and lower jaw · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    Listed among the outcome measures evaluated by Almeida 2005. No separate width/expansion estimate is reported in the text; the review concluded the interventions produced no significant change in the skeletal maxillary…
    1 study
    GRADE not reported

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Patient satisfaction · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Signs and symptoms of atypical swallowing and speech production disturbances · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Signs and symptoms of respiratory disease · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Repelling-magnet splints vs Bite-blocks

Side effects / adverse effects (unilateral crossbite; transverse problems) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    About 4 months (treatment interrupted early)
    "After 4 months the open bite was observed to close in the magnet group, but in four out of these ten patients, transverse problems were observed (unilateral crossbite) which led to the interruption of the treatment…
    1 study · 10 participants
    GRADE not reported

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Position of the incisors (upper incisor inclination) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (about 2 years)
    The angulation of the upper incisors with the palatal plane (1/ANSPNS) decreased on average 0.3 (SD 4.6) degrees in the control group, whereas in the treated group the mean retrusion was 4 (SD 4.6) degrees, P < 0.01.…
    1 study
    GRADE not reported

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Alteration of hyperdivergent growth pattern · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (about 2 years)
    Multiple cephalometric measures reported (Erbay 1995). Treated group: total anterior facial height (N-Me) +3.9 (SD 1.8) mm, upper anterior facial height (N-ANS) +3.3 (SD 1.2) mm; controls showed significantly greater…
    1 study
    GRADE not reported

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Economic evaluation (costs) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Time to recovery from fever (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in time to recovery from fever (lower values signify better outcomes) compared with antibiotics alone (low certainty).

1 finding from 1 review

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Time to withdrawal from ATB (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in time to withdrawal from ATB (lower values signify better outcomes) compared with antibiotics alone (low certainty).

1 finding from 1 review