Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Retzius‐sparing RALP vs standard RALP

Urinary continence 12 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Retzius‐sparing RALP showed no clear difference in urinary continence 12 months after surgery MCID: 5% absolute… compared with standard RALP (moderate certainty).

1 finding from 1 review

Retzius‐sparing RALP vs standard RALP

Potency 12 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

It is very uncertain whether retzius‐sparing RALP changes potency 12 months after surgery MCID: 5% absolute difference compared with standard RALP (very low certainty).

1 finding from 1 review

Second‐generation endometrial ablation vs first‐generation endometrial ablation

Requirement for additional (surgical) interventions · heavy menstrual bleeding

Overall analyses: second‐generation endometrial ablation showed no clear difference in requirement for additional surgery compared with first‐generation endometrial ablation (low certainty).

1 finding from 1 review

Laparoscopic colposuspension with one suture vs laparoscopic colposuspension with two sutures

Repeat surgery for urinary incontinence · women with urinary incontinence

Laparoscopic colposuspension with one suture showed no clear difference in repeat continence surgery: compared with laparoscopic colposuspension with two sutures (low certainty).

1 finding from 1 review

Laparoscopic colposuspension with sutures vs laparoscopic colposuspension with mesh and staples

Repeat surgery for urinary incontinence · women with urinary incontinence

It is very uncertain whether laparoscopic colposuspension with sutures changes repeat continence surgery: compared with laparoscopic colposuspension with mesh and staples (very low certainty).

1 finding from 1 review

Alteplase vs urokinase

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

Alteplase showed no clear difference in overall treatment failure, including mortality, thoracic surgery or… compared with urokinase (low certainty).

1 finding from 1 review

Fibrinolytics vs placebo

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

It is very uncertain whether fibrinolytics changes overall treatment failure, including mortality, thoracic surgery or… compared with placebo (very low certainty).

1 finding from 1 review

Streptokinase vs urokinase

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

Streptokinase showed no clear difference in overall treatment failure, including mortality, thoracic surgery or… compared with urokinase (low certainty).

1 finding from 1 review

Intervention not reported

Complete resolution of symptoms (proportion of patients with 'immediate and persistent resolution of symptoms' from the point of surgery/randomisation up to end of study · children with PFAPA

The intervention showed no clear difference in complete resolution of symptoms (proportion of patients with… (moderate certainty).

1 finding from 1 review

Surgical vs conservative interventions

Treatment failure (indication for non‐routine secondary surgery) · adults (aged ≥ 16 years) with acute middle third clavicle fractures

Surgical may leads to lower treatment failuref Indication for non‐routine secondary surgery compared with conservative interventions (low certainty).

1 finding from 1 review

Hysterectomy with opportunistic salpingectomy vs hysterectomy without opportunistic salpingectomy

Surgery‐related adverse events: intraoperative complications · premenopausal women undergoing hysterectomy for benign gynaecological indications

It is very uncertain whether hysterectomy with opportunistic salpingectomy changes surgery‐related adverse events: intraoperative complications compared with hysterectomy without opportunistic salpingectomy (very low certainty).

1 finding from 1 review

Hysterectomy with opportunistic salpingectomy vs hysterectomy without opportunistic salpingectomy

Surgery‐related adverse events: short‐term postoperative complications · premenopausal women undergoing hysterectomy for benign gynaecological indications

It is very uncertain whether hysterectomy with opportunistic salpingectomy changes surgery‐related adverse events: short‐term postoperative complications compared with hysterectomy without opportunistic salpingectomy (very low certainty).

1 finding from 1 review