Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,192 questions · 1,243 findings · 151 reviews

No studies found 252 · 20.3%GRADE not reported 180 · 14.5%Very low 291 · 23.4%Low 282 · 22.7%Moderate 174 · 14%High 64 · 5.1%

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Perineal trauma · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes perineal trauma compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Induction of labour · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes induction of labour compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review

Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)

Aesthetics · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
1 finding from 1 review
  • Primary outcome aesthetic evaluation data were reported as the frequency of distribution of the Implant Crown Aesthetic Index (ICAI); no comparative summary estimate was presented.
    2 studies · 47 participants
    Very low

IRI with fluoropyrimidines vs single agent IRI

Progression‐free survival (PSF) · patients with advanced and/or metastatic colorectal cancer

IRI with fluoropyrimidines probably leads to lower progression‐free survival (Disease progression) compared with single agent IRI (moderate certainty).

1 finding from 1 review

Root canal medications and canal filling, splinting, extraction of teeth, or surgical removal of any relevant pathology vs Each other, placebo, or no treatment

Outcome not reported · Patients with single and multiple permanent teeth with evidence of any type of external root resorption irrespective of its aetiology,…

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for the management of external root resorption 2015 · Cochrane All outcomes
    Any follow-up period
    None of the studies fulfilled our inclusion criteria and therefore no data analysis was conducted. (Main results: no RCTs that met the inclusion criteria were identified; one ongoing study, NCT00423956, potentially…
    0 studies
    No studies found

Laminectomy plus radiotherapy vs radiotherapy

Ambulation · adults with metastatic extradural spinal cord compression (single lesion, no prior radiotherapy, fit for surgery)

It is very uncertain whether laminectomy plus radiotherapy changes ambulation At four months compared with radiotherapy (very low certainty).

1 finding from 1 review