On‐study mortality3 (Subnet based on 55 studies including 15,074 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).
1 finding from 1 review
RR 0.13 [0.01, 2.29]
Studies not reported
Low
Red blood cell transfusions (Subnet based on 69 studies including 18,684 participants) · patients at any age with solid cancer or haematological malignancy
IV or oral iron alone showed no clear difference in red blood cell transfusions (Subnet based on 69 studies including… compared with no treatment (low certainty).
1 finding from 1 review
RR 0.74 [0.43, 1.28]
Studies not reported
Low
Overall mortality4 (Subnet based on 71 studies including 21,576 participants) · patients at any age with solid cancer or haematological malignancy
IV or oral iron alone showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).
1 finding from 1 review
RR 1.5 [0.63, 3.56]
Studies not reported
Low
Thromboembolic events · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Thrombocytopenia or haemorrhage5 (Subnet based on 13 studies including 2744 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hypertension5 (Subnet based on 24 studies including 8383 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Haemoglobin response (Subnet based on 31 studies including 6985 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron probably leads to higher haemoglobin response (Subnet based on 31 studies including 6985… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 6.71 [4.93, 9.14]
Studies not reported
Moderate
Red blood cell transfusions (Subnet based on 69 studies including 18,684 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron probably leads to lower red blood cell transfusions (Subnet based on 69 studies including… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 0.44 [0.31, 0.63]
Studies not reported
Moderate
Overall mortality4 (Subnet based on 71 studies including 21,576 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).
1 finding from 1 review
RR 1.46 [0.87, 2.43]
Studies not reported
Low
Thromboembolic events · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in thromboembolic events5 (Subnet based on 50 studies including 15,408… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 1.82 [0.98, 3.41]
Studies not reported
Moderate
Thrombocytopenia or haemorrhage5 (Subnet based on 13 studies including 2744 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hypertension5 (Subnet based on 24 studies including 8383 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
On‐study mortality3 (Subnet based on 55 studies including 15,074 participants) · patients at any age with solid cancer or haematological malignancy
IV or oral iron alone showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).
1 finding from 1 review
RR 2.95 [0.71, 12.34]
Studies not reported
Low
Haemoglobin response (Subnet based on 31 studies including 6985 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Functional outcomes · people with stroke upon awakening
Endovascular treatment leads to higher independent functional outcome at end of compared with standard medical care (high certainty).
1 finding from 1 review
Intracranial haemorrhage · people with stroke upon awakening
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Death at · people with stroke upon awakening
Endovascular treatment showed no clear difference in death at compared with standard medical care (high certainty).
1 finding from 1 review
At least 50% reduction in pain · health problem or population
It is very uncertain whether summary of Findings Table ‐ Ibuprofen changes number of participants with at least 50% pain relief at 4 hours compared with placebo (very low certainty).
2 findings from 1 review
Median (mean) time to use of rescue medication · health problem or population
1 finding from 1 review
Number of participants reporting an adverse event · health problem or population
It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants reporting or experiencing any adverse event compared with active comparator (acetaminophen) (very low certainty).
1 finding from 1 review