Findings

What do systematic reviews say?

3,801 questions · 4,079 findings · 473 reviews

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No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Oral phenylbutyrate vs placebo

Change in pulmonary function · children with SMA type II

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 67 participants
Low

Oral creatine vs placebo

Change in pulmonary function · children with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23 participants
Low

Subcutaneous somatotropin vs placebo

Change in pulmonary function · children and adults with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
19 participants
Low

Intravenous thyrotropin releasing hormone vs placebo

Change in pulmonary function · children with SMA types II and III

The review found no eligible studies for this question.

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral valproic acid plus acetyl‐L‐carnitine vs placebo

Change in pulmonary function · non‐ambulatory children with SMA types II and III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Oral valproic acid vs placebo

Change in pulmonary function · ambulatory adults with SMA type III

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
no estimate extracted
24 participants
Low

Summary of findings: ECM vs ECT

Pulmonary exacerbations · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs ECMM

Pulmonary exacerbations · children with cystic fibrosis and proven pancreatic insufficiency

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs a different ECM

Pulmonary exacerbations · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs TPE

Pulmonary exacerbations · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs other enteric‐coated preparations

Pulmonary exacerbations · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: low‐dose vs high‐dose PERT

Pulmonary exacerbations · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: liprotamase vs porcine PERT

Pulmonary exacerbations · children aged 7 years or over and adults with cystic fibrosis

Summary of findings: liprotamase showed no clear difference in pulmonary exacerbations: number of exacerbations compared with porcine PERT (low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
OR 0.56 [0.13, 2.45]
1 study · 128 participants
Low

Summary of findings: ECM vs NECT plus cimetidine

Pulmonary exacerbations · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Treatment failure day‐28 PCR‐adjusted(PP population) · children aged 14 years or younger with uncomplicated P falciparum malaria

The intervention showed no clear difference in treatment failure day‐28 PCR‐adjusted(PP population) (low certainty).

1 finding from 1 review

Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children 2020 · Cochrane Headline outcomes only
RR 1.35 [0.49, 3.72]
2 studies · 1061 participants
Low

Intervention not reported

Treatment failureday‐28 PCR‐adjusted(ITT population) · children aged 14 years or younger with uncomplicated P falciparum malaria

The intervention showed no clear difference in treatment failureday‐28 PCR‐adjusted(ITT population) (low certainty).

1 finding from 1 review

Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children 2020 · Cochrane Headline outcomes only
RR 1.05 [0.68, 1.62]
2 studies · 1139 participants
Low

CBT vs alternative interventions

Emotional self‐regulation and impulse control (no study reported data on this outcome) · young people (aged 10 to 18 years old) with harmful sexual behaviour

The review found no eligible studies for this question.

1 finding from 1 review

Cognitive‐behavioural therapy (CBT) interventions for young people aged 10 to 18 with harmful sexual behaviour 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

CBT vs no treatment or treatment

Emotional self‐regulation and impulse control (no study reported data on this outcome) · young people (aged 10 to 18 years old) with harmful sexual behaviour

The review found no eligible studies for this question.

1 finding from 1 review

Cognitive‐behavioural therapy (CBT) interventions for young people aged 10 to 18 with harmful sexual behaviour 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs other intracranial pressure‐lowering agents

Pulmonary oedema · people with acute traumatic brain injury

The review found no eligible studies for this question.

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo

Pulmonary exacerbations · children and adults with CF

1 finding from 1 review

Probiotics for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 225 participants
Low