Cochrane · systematic review · CD010904

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury

Chen, H, Song, Z, Dennis, JA · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library

Injuries2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 2 · 28.6%Ungraded 0 · 0%Very low 5 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Hypertonic saline compared with other intracranial pressure‐lowering agents for acute traumatic brain injury

Population: people with acute traumatic brain injury

7 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality (short‐term) Hypertonic saline vs other intracranial pressure‐lowering agents	RR 0.33	2 studies · 70 participants	Very low Downgraded: risk of bias, imprecision, indirectness
Mortality at 6 months Hypertonic saline vs other intracranial pressure‐lowering agents	RR 0.84 [0.46, 1.55]	2 studies · 85 participants	Very low Downgraded: risk of bias, imprecision, inconsistency
Glasgow Outcome Scale: poor outcome at 6 months Hypertonic saline vs other intracranial pressure‐lowering agents	RR 1.09 [0.82, 1.44]	2 studies · 85 participants	Very low Downgraded: risk of bias, imprecision, inconsistency
Uncontrolled ICP during treatment Hypertonic saline vs other intracranial pressure‐lowering agents	no estimate extracted	6 studies · 287 participants	Very low Downgraded: risk of bias, imprecision, inconsistency
A rebound phenomenon during treatment Hypertonic saline vs other intracranial pressure‐lowering agents	no estimate extracted	1 study · 32 participants	Very low Downgraded: risk of bias, imprecision, indirectness
Pulmonary oedema during treatment Hypertonic saline vs other intracranial pressure‐lowering agents	no estimate extracted	NR	No studies
Acute renal failure during treatment Hypertonic saline vs other intracranial pressure‐lowering agents	no estimate extracted	NR	No studies