Cochrane · systematic review · CD010904
Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury
Chen, H, Song, Z, Dennis, JA · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 5 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHypertonic saline compared with other intracranial pressure‐lowering agents for acute traumatic brain injury
Population: people with acute traumatic brain injury
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality (short‐term) Hypertonic saline vs other intracranial pressure‐lowering agents | RR 0.33 | 2 studies · 70 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Mortality at 6 months Hypertonic saline vs other intracranial pressure‐lowering agents | RR 0.84 [0.46, 1.55] | 2 studies · 85 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Glasgow Outcome Scale: poor outcome at 6 months Hypertonic saline vs other intracranial pressure‐lowering agents | RR 1.09 [0.82, 1.44] | 2 studies · 85 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Uncontrolled ICP during treatment Hypertonic saline vs other intracranial pressure‐lowering agents | no estimate extracted | 6 studies · 287 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
A rebound phenomenon during treatment Hypertonic saline vs other intracranial pressure‐lowering agents | no estimate extracted | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Pulmonary oedema during treatment Hypertonic saline vs other intracranial pressure‐lowering agents | no estimate extracted | NR | No studies |
Acute renal failure during treatment Hypertonic saline vs other intracranial pressure‐lowering agents | no estimate extracted | NR | No studies |
Hypertonic saline compared with other intracranial pressure‐lowering agents for acute traumatic brain injury
Population: people with acute traumatic brain injury
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality (short‐term) Hypertonic saline vs other intracranial pressure‐lowering agents | RR 0.33 | 2 studies · 70 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Mortality at 6 months Hypertonic saline vs other intracranial pressure‐lowering agents | RR 0.84 [0.46, 1.55] | 2 studies · 85 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Glasgow Outcome Scale: poor outcome at 6 months Hypertonic saline vs other intracranial pressure‐lowering agents | RR 1.09 [0.82, 1.44] | 2 studies · 85 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Uncontrolled ICP during treatment Hypertonic saline vs other intracranial pressure‐lowering agents | no estimate extracted | 6 studies · 287 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
A rebound phenomenon during treatment Hypertonic saline vs other intracranial pressure‐lowering agents | no estimate extracted | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Pulmonary oedema during treatment Hypertonic saline vs other intracranial pressure‐lowering agents | no estimate extracted | NR | No studies |
Acute renal failure during treatment Hypertonic saline vs other intracranial pressure‐lowering agents | no estimate extracted | NR | No studies |