Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,087 questions · 2,360 findings · 390 reviews

No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Both one‐to‐one and group counselling · developing countries

Community health educational one‐to‐one and group and both… probably leads to lower early neonatal mortality ‐ Both one‐to‐one and group counselling compared with control (moderate certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during ANC period only · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes early neonatal mortality ‐ Education provided during ANC period only compared with control (very low certainty).

1 finding from 1 review

Community health educational interventions vs control

Early neonatal mortality · developing countries

It is very uncertain whether community health educational interventions changes early neonatal mortality compared with control (very low certainty).

2 findings from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during PNC period only · developing countries

Community health educational ANC period and PNC period and both… showed no clear difference in early neonatal mortality ‐ Education provided during PNC period only compared with control (moderate certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during both ANC and PNC periods · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes early neonatal mortality ‐ Education provided during both ANC and… compared with control (very low certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Early neonatal mortality ‐ Intervention given to mothers and family members · developing countries

It is very uncertain whether community health educational intervention for family members and… changes early neonatal mortality ‐ Intervention given to mothers and family… compared with control (very low certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Early neonatal mortality ‐ Intervention given to mothers only · developing countries

It is very uncertain whether community health educational intervention for family members and… changes early neonatal mortality ‐ Intervention given to mothers only compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Group counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to lower early neonatal mortality ‐ Group counselling compared with control (low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ One‐to‐one counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to higher early neonatal mortality ‐ One‐to‐one counselling compared with control (low certainty).

1 finding from 1 review

ECT plus standard care vs usual care

Satisfaction and acceptability of treatment (medium term) ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether ECT plus standard care changes satisfaction and acceptability of treatment (medium term) ‐ leaving… compared with standard care (very low certainty).

1 finding from 1 review

Aspirin plus antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

It is very uncertain whether aspirin plus antipsychotics changes leaving the study early: short‐term – for any reason compared with placebo plus antipsychotics (very low certainty).

1 finding from 1 review

Padded moulded double‐rocker plaster shoe vs padded below‐knee plaster

Ulcer healing · ulceration and other skin changes caused by nerve damage in leprosy

It is very uncertain whether padded moulded double‐rocker plaster shoe changes primary outcome: healing of ulcer (ulcers fully or nearly healed at… compared with padded below‐knee plaster (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids showed no clear difference in satisfaction with treatment: leaving the study early Long‐term… compared with placebo (low certainty).

1 finding from 1 review

Group B antipsychotic drugs: amisulpiride + needs‐focused intervention vs needs‐focused intervention

Satisfaction with treatment: leaving the study early Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B antipsychotic drugs: amisulpiride + needs‐focused intervention changes satisfaction with treatment: leaving the study early Endpoint data… compared with needs‐focused intervention (very low certainty).

1 finding from 1 review

Group B antipsychotic drugs: olanzapine + supportive intervention vs placebo or supportive treatment

Satisfaction and acceptability of treatment (medium term) ‐ leaving the study early · people in the prodromal stage of psychosis

It is very uncertain whether group B antipsychotic drugs: olanzapine + supportive intervention changes satisfaction with treatment: leaving the study early Endpoint data… compared with placebo + supportive intervention (very low certainty).

1 finding from 1 review