Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

92 questions · 92 findings · 16 reviews · Heart

No studies found 7 · 7.6%GRADE not reported 0 · 0%Very low 26 · 28.3%Low 29 · 31.5%Moderate 27 · 29.3%High 3 · 3.3%

Prophylactic levosimendan vs usual care

Mechanical circulatory support or cardiac transplantation · paediatric patients following heart surgery

Prophylactic levosimendan showed no clear difference in mechanical circulatory support or cardiac transplantation compared with standard treatment (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality · individuals with atrial fibrillation who are undergoing cardiac surgery

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review

Intervention not reported

Freedom from AF/AFL/AT off antiarrhythmic medications > 3 months · individuals with atrial fibrillation who are undergoing cardiac surgery

The intervention probably leads to higher freedom from AF/AFL/AT off antiarrhythmic medications > 3 months (moderate certainty).

1 finding from 1 review

Intervention not reported

Investigator‐defined adverse events · individuals with atrial fibrillation who are undergoing cardiac surgery

It is very uncertain whether the intervention changes investigator‐defined adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Pacemaker implantation4 · individuals with atrial fibrillation who are undergoing cardiac surgery

The intervention probably leads to higher pacemaker implantation4 (moderate certainty).

1 finding from 1 review

Intervention not reported

30‐day mortality4 · individuals with atrial fibrillation who are undergoing cardiac surgery

The intervention showed no clear difference in 30‐day mortality4 (low certainty).

1 finding from 1 review

Fresh frozen plasma vs no plasma

Number of participants receiving a red cell transfusion (total) · Neonates, children and adults undergoing cardiovascular surgery

Fresh frozen plasma probably leads to higher number of patients receiving a red cell transfusion compared with no plasma (moderate certainty).

1 finding from 1 review

Fresh frozen plasma vs no plasma

Resource use: need for return to theatre · Neonates, children and adults undergoing cardiovascular surgery

Fresh frozen plasma showed no clear difference in resource use: need for return to theatre compared with no plasma (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality · patients undergoing cardiac surgery

The intervention showed no clear difference in mortality (moderate certainty).

1 finding from 1 review

Intervention not reported

Myocardial infarction ECG/cardiac enzymes · patients undergoing cardiac surgery

The intervention showed no clear difference in myocardial infarction ECG/cardiac enzymes (low certainty).

1 finding from 1 review

Intervention not reported

Atrial fibrillation ECG · patients undergoing cardiac surgery

The intervention probably leads to lower atrial fibrillation ECG (moderate certainty).

1 finding from 1 review