Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

281 questions · 285 findings · 20 reviews · Skin

No studies found 42 · 14.7%GRADE not reported 88 · 30.9%Very low 22 · 7.7%Low 75 · 26.3%Moderate 47 · 16.5%High 11 · 3.9%

Oral methotrexate vs placebo

Primary outcome: complete clinical response (malar/discoid rash) · patients with cutaneous disease in systemic lupus erythematosus

Oral methotrexate may leads to higher primary outcome: complete clinical response (malar/discoid rash) compared with placebo (low certainty).

1 finding from 1 review