Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

108 questions · 109 findings · 17 reviews · Pain, Palliative and Supportive Care

No studies found 16 · 14.7%GRADE not reported 5 · 4.6%Very low 54 · 49.5%Low 9 · 8.3%Moderate 10 · 9.2%High 15 · 13.8%

NSAIDs vs placebo

Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes substantial pain relief: at least 50% reduction in pain, or PGIC… compared with placebo (very low certainty).

1 finding from 1 review

NSAIDs vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes moderate pain relief: at least 30% reduction in pain, or PGIC much… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Participants with at least 30% or at least 50% reduction in pain · people with cancer pain
1 finding from 1 review

Intervention not reported

PGIC much or very much improved · people with cancer pain
1 finding from 1 review

Intervention not reported

Mean pain intensity at end of study · people with cancer pain
1 finding from 1 review

Intervention not reported

Pain no worse than mild at one or two weeks (or equivalent) · people with cancer pain
1 finding from 1 review

Intervention not reported

Mean quality of life or "well‐being" · people with cancer pain
1 finding from 1 review

Intervention not reported

Participant preference · people with cancer pain
1 finding from 1 review

Intervention not reported

Serious adverse events · people with cancer pain
1 finding from 1 review