Overall survival · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral showed no clear difference in overall survival compared with intravenous fluoropyrimidines (high certainty).
1 finding from 1 review
Grade ≥ 3 diarrhoea · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral may leads to higher grade ≥ 3 diarrhoea compared with intravenous fluoropyrimidines (low certainty).
1 finding from 1 review
Hand‐foot syndrome (grade ≥ 3) · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy
Oral probably leads to higher grade ≥ 3 hand foot syndrome compared with intravenous fluoropyrimidines (moderate certainty).
1 finding from 1 review
QoL · Women in the peri‐ or postmenopausal phase
2 findings from 1 review
Side effects: acne ‐ oral administration · Women in the peri‐ or postmenopausal phase
It is very uncertain whether oral DHEA changes side effects: acne ‐ oral administration compared with control subgrouped by differing routes of administration (very low certainty).
1 finding from 1 review
Oral health problems (mucositis, caries, candidiasis) · Children with leukemia in the United Arab Emirates
One study found oral problems in 60% of children with leukemia, most common during maintenance therapy and among those treated locally (narrative synthesis; not GRADE-rated).
1 finding from 1 review
Alnuaimi et al. reported a 60% prevalence of oral problems (mostly oral mucositis/ulceration, then dental caries and oral candidiasis) among children with leukemia; prevalence was not associated with age, gender,…
1 study
GRADE not reported
Presence of oral disease · people with stroke
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Stroke survivor and providers' knowledge and attitudes to oral health care · people with stroke
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Gingivitis · people with stroke
1 finding from 1 review
Denture-induced stomatitis · people with stroke
1 finding from 1 review
Oral health status (caries, DMFT, calculus, erosion, malocclusion, treatment indices) · Children with Down syndrome in Dubai
One study found children with Down syndrome had similar caries prevalence but higher DMFT, calculus, erosion and malocclusion than controls, with better restorative-care access (narrative synthesis; not GRADE-rated).
1 finding from 1 review
Ghaith et al. (Dubai) reported dental decay in 57.6% of children with Down syndrome (same as controls) but a higher mean DMFT (2.73 vs 1.65) and calculus index (0.25 vs 0.07), higher erosion prevalence/severity, and…
1 study
GRADE not reported
Oral health status (caries, gingivitis, calculus, treatment indices) · Children with cerebral palsy in Dubai
One study found children with cerebral palsy had caries and gingivitis similar to matched controls but more calculus and anomalies, with lower restorative care despite greater need (narrative synthesis; not GRADE-rated).
1 finding from 1 review
Al Hashmi et al. (Dubai) reported caries in 53% of children with cerebral palsy (mean DMFT 2.83) and gingivitis in 58.8%, similar to matched controls, but a significantly higher calculus index (0.56 vs 0.07) and more…
1 study
GRADE not reported
Oral health knowledge of carers (medium term) · People with mixed levels of ID (age range unclear); setting residential
Oral hygiene care training of carers may leads to higher oral health knowledge of carers (medium term) compared with no training (or a placebo training session) of carers (low certainty).
1 finding from 1 review
Oral mucositis (severe) · Adults with cancer receiving treatment
Epidermal growth factor (EGF), oral spray showed no clear difference in oral mucositis (severe) compared with placebo; GRADE not reported.
1 finding from 1 review
Oral mucositis (moderate to severe) · Adults with cancer receiving treatment
Epidermal growth factor (EGF), oral spray showed no clear difference in oral mucositis (moderate to severe) compared with placebo; GRADE not reported.
2 findings from 1 review
Oral health status (caries, calculus, gingivitis) · Children with beta-thalassemia major in Dubai
One study found higher caries and calculus but lower gingivitis and restorative care in children with beta-thalassemia major compared with healthy Emirati children (narrative synthesis; not GRADE-rated).
1 finding from 1 review
Oral mucositis (moderate to severe) · Adults receiving chemotherapy alone for colorectal cancer
Intestinal trefoil factor (ITF), oral spray led to lower oral mucositis (moderate to severe) compared with placebo; GRADE not reported.
1 finding from 1 review
Oral mucositis (any severity) · Adults receiving chemotherapy alone for colorectal cancer
Intestinal trefoil factor (ITF), oral spray led to lower oral mucositis (any severity) compared with placebo; GRADE not reported.
1 finding from 1 review
Oral mucositis (severe) · Adults receiving chemotherapy alone for colorectal cancer
Intestinal trefoil factor (ITF), oral spray showed no clear difference in oral mucositis (severe) compared with placebo; GRADE not reported.
1 finding from 1 review
Reduction in pain · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review