Findings

What do systematic reviews say?

125 questions · 125 findings · 10 reviews · Pregnancy and Childbirth

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No studies found 15 · 12%GRADE not reported 8 · 6.4%Very low 42 · 33.6%Low 48 · 38.4%Moderate 12 · 9.6%High 0 · 0%

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Uterine hyperstimulation with fetal heart rate changes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes uterine hyperstimulation with FHR changes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 3 [0.12, 72.45]
1 study · 146 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Oxytocin augmentation · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes oxytocin augmentation compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.04 [0.85, 1.27]
2 studies · 296 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Uterine hyperstimulation without fetal heart rate changes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes uterine hyperstimulation without FHR changes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 4 [0.88, 18.2]
1 study · 146 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Apgar score less than 7 at 5 minutes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes apgar score less than 7 at 5 minutes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1 [0.32, 3.16]
2 studies · 296 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Admission to neonatal intensive care unit · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes admission to NICU compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.38 [0.57, 3.31]
2 studies · 296 participants
Very low

Vaginal misoprostol vs placebo

Complete miscarriage · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to higher complete miscarriage compared with placebo (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 4.23 [3.01, 5.94]
5 studies · 305 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Nausea · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to higher nausea compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 21.85 [1.31, 364.37]
1 study · 154 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Diarrhoea · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to higher diarrhoea compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 40.85 [2.52, 662.57]
1 study · 154 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Blood loss: post‐treatment haematocrit (%) · early fetal death (less than 24 weeks)

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to higher pain relief compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 1.42
1 study · 154 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Woman’s satisfaction/acceptability of method · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in woman’s satisfaction/acceptability of method compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 0.67 [0.4, 1.11]
1 study · 45 participants
Low

Vaginal misoprostol vs placebo

Pelvic infection · early fetal death (less than 24 weeks)

The review found no eligible studies for this question.

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vaginal misoprostol vs placebo

Nausea · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in nausea compared with placebo (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 1.38 [0.43, 4.4]
2 studies · 88 participants
Low

Vaginal misoprostol vs placebo

Diarrhoea · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in diarrhoea compared with placebo (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 2.21 [0.35, 14.06]
2 studies · 88 participants
Low

Vaginal misoprostol vs placebo

Blood loss: haemoglobin difference > 10 g/L · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes blood loss: haemoglobin difference > 10 g/L compared with placebo (very low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 1.25 [0.38, 4.12]
1 study · 50 participants
Very low

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 5 [0.25, 101.11]
1 study · 84 participants
Very low

Vaginal misoprostol vs placebo

Woman’s satisfaction/acceptability of method · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in woman’s satisfaction/acceptability of method compared with placebo (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 1.17 [0.83, 1.64]
1 study · 32 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Complete miscarriage · early fetal death (less than 24 weeks)

Vaginal misoprostol may leads to lower complete miscarriage compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 0.4 [0.32, 0.5]
6 studies · 943 participants
Low

Vaginal misoprostol vs surgical evacuation of uterus

Pelvic infection · early fetal death (less than 24 weeks)

Vaginal misoprostol showed no clear difference in pelvic infection compared with surgical evacuation of uterus (low certainty).

1 finding from 1 review

Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
RR 0.73 [0.39, 1.37]
1 study · 618 participants
Low

Vaginal misoprostol vs placebo

Vaginal delivery not achieved within 24 hours · women requiring induction of labour

1 finding from 1 review

Pharmacological and mechanical interventions for labour induction in outpatient settings 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported