Findings

What do systematic reviews say?

132 questions · 135 findings · 30 reviews · Neonatal

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No studies found 16 · 11.9%GRADE not reported 14 · 10.4%Very low 30 · 22.2%Low 45 · 33.3%Moderate 27 · 20%High 3 · 2.2%

Intervention not reported

Percentage of infants that showed improvement in OI by at least 20% by the end of therapy · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
39 participants
Low

Intervention not reported

Duration of iNO therapy (days) · Neonates with PPHN

1 finding from 1 review

Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
21 participants
Low

Epinephrine vs placebo, no treatment or any other drugs

Duration of oxygen therapy (hours) · patients with the management of transient tachypnea of the newborn

1 finding from 1 review

Epinephrine for transient tachypnea of the newborn 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Neonatal mortality · preterm infants at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Mortality before hospital discharge · preterm infants at risk of respiratory distress syndrome

It is very uncertain whether surfactant treatment guided by rapid tests for surfactant deficiency changes mortality prior to hospital discharge№ of participants: 562 (3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (very low certainty).

1 finding from 1 review

Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome 2023 · Cochrane Headline outcomes only
RR 1.25 [0.65, 2.41]
Studies not reported
Very low

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Bronchopulmonary dysplasia · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in bronchopulmonary dysplasia№ of participants: 562(3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome 2023 · Cochrane Headline outcomes only
RR 0.9 [0.61, 1.32]
Studies not reported
Low

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Bronchopulmonary dysplasia or mortality ‐ not reported · preterm infants at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Surfactant utilization № of participants: 562 (3 RCTs) · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in surfactant utilization № of participants: 562 (3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome 2023 · Cochrane Headline outcomes only
RR 0.97 [0.85, 1.11]
Studies not reported
Low

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Pneumothorax · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in any pneumothorax№ of participants: 506(2 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome 2023 · Cochrane Headline outcomes only
RR 0.53 [0.15, 1.92]
Studies not reported
Low

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Neurodevelopmental outcomes · preterm infants at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Turning position vs supine under phototherapy

Need for exchange transfusion · term and preterm neonates with hyperbilirubinaemia

The review found no eligible studies for this question.

1 finding from 1 review

Periodic change of body position under phototherapy in term and preterm neonates with hyperbilirubinaemia 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Turning position vs supine under phototherapy

Bilirubin‐induced neurological damage (BIND) · term and preterm neonates with hyperbilirubinaemia

The review found no eligible studies for this question.

1 finding from 1 review

Periodic change of body position under phototherapy in term and preterm neonates with hyperbilirubinaemia 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Turning position vs supine under phototherapy

Sudden infant death syndrome · term and preterm neonates with hyperbilirubinaemia

The review found no eligible studies for this question.

1 finding from 1 review

Periodic change of body position under phototherapy in term and preterm neonates with hyperbilirubinaemia 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Reflective curtains vs intensified phototherapy

Acute life‐threatening events · newborn infants with unconjugated hyperbilirubinaemia

1 finding from 1 review

Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 159 participants
GRADE not reported

Reflective curtains vs intensified phototherapy

Patient satisfaction · newborn infants with unconjugated hyperbilirubinaemia

1 finding from 1 review

Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 159 participants
GRADE not reported

Reflective curtains vs intensified phototherapy

Any breastfeeding at hospital discharge · newborn infants with unconjugated hyperbilirubinaemia

1 finding from 1 review

Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 159 participants
GRADE not reported

Reflective curtains vs intensified phototherapy

Decline in bilirubin (first measurement) · newborn infants with unconjugated hyperbilirubinaemia

1 finding from 1 review

Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 159 participants
Low

Reflective curtains vs intensified phototherapy

Exchange transfusion · newborn infants with unconjugated hyperbilirubinaemia

1 finding from 1 review

Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 159 participants
GRADE not reported

nHFV vs invasive respiratory therapy

Mortality before hospital discharge · preterm infants with respiratory distress for initial respiratory support

It is very uncertain whether nHFV changes mortality before hospital discharge compared with invasive respiratory therapy (very low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 0.67 [0.2, 2.18]
1 study · 80 participants
Very low

nHFV vs invasive respiratory therapy

Endotracheal intubation or reintubation To discharge · preterm infants with respiratory distress for initial respiratory support

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported