Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 205 findings · 42 reviews

No studies found 23 · 11.2%GRADE not reported 64 · 31.2%Very low 31 · 15.1%Low 51 · 24.9%Moderate 33 · 16.1%High 3 · 1.5%

Steroids vs cyclosporine A

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids showed no clear difference in change in TBUT (seconds) (longer is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs lubricants

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids may leads to higher change in TBUT (seconds) (longer is favored) compared with lubricants (low certainty).

1 finding from 1 review

Surgery with excision of failed tape vs surgery without excision of tape

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Repeat midurethral tape (any type) vs any other non‐tape surgical treatment (e.g. traditional sling, colposuspension, injectables)

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

One type of repeat midurethral tape vs another type of repeat midurethral tape

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Acute stroke (within 30‐days after surgery: new focal neurologic deficit with signs and symptoms lasting longer than 24 hours) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists may leads to lower acute stroke (within 30‐days after surgery: new focal neurologic… compared with control (low certainty).

1 finding from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Response (50% reduction in BDI) long term (longer than 12 months)* · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in BDI) long term (longer than 12 months)* compared with usual care alone (low certainty).

1 finding from 1 review

Epidermal growth factor (EGF), oral spray vs placebo

Interruptions to cancer treatment (radiotherapy breaks longer than two days) · Adults with cancer receiving treatment

Epidermal growth factor (EGF), oral spray showed no clear difference in interruptions to cancer treatment (radiotherapy breaks longer than… compared with placebo; GRADE not reported.

1 finding from 1 review