Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

319 questions · 326 findings · 34 reviews · Airways

No studies found 21 · 6.4%GRADE not reported 22 · 6.7%Very low 20 · 6.1%Low 81 · 24.8%Moderate 132 · 40.5%High 50 · 15.3%

Pharmacological treatment vs placebo

Prolonged abstinence at longest · smokers with COPD

Pharmacological treatment leads to higher prolonged abstinence at longest compared with placebo (high certainty).

5 findings from 1 review
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Intervention vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · COPD and at least one other long‐term condition

It is very uncertain whether intervention changes exacerbations ‐ number of people experiencing one or more  compared with usual care (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Children not cured or substantially improved at · prolonged wet cough in children

Antibiotics probably leads to lower children not cured or substantially improved at compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Children with progression of the disease resulting in additional medical therapy (complications) (measured as proportion of participants) · prolonged wet cough in children

Antibiotics probably leads to lower children with progression of the disease resulting in additional… compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Adverse effects of antibiotics · prolonged wet cough in children

Antibiotics showed no clear difference in children experiencing adverse effects of antibiotics (e.g.… compared with placebo (low certainty).

1 finding from 1 review