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What do systematic reviews say?

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Evidence found and GRADE certainty

230 questions · 235 findings · 17 reviews

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No studies found 71 · 30.2%GRADE not reported 17 · 7.2%Very low 70 · 29.8%Low 49 · 20.9%Moderate 20 · 8.5%High 8 · 3.4%

Lidocaine vs aprindine

Specific behaviour ‐ agitation · patients with myocardial infarction

It is very uncertain whether lidocaine changes agitation compared with aprindine (very low certainty).

1 finding from 1 review

Lidocaine vs pirmenol

Adverse events (any type) and safety of sealant · patients with myocardial infarction

It is very uncertain whether lidocaine changes safety (AEs; adverse drug reaction): any adverse event compared with pirmenol (very low certainty).

1 finding from 1 review

Lidocaine vs placebo or no intervention

Adverse events (AEs; adverse drug reaction): sinus bradycardia · patients with acute myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): sinus bradycardia compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Lidocaine vs placebo or no intervention

Adverse events (AEs; adverse drug reaction): drowsiness/dizziness · patients with acute myocardial infarction

Lidocaine may leads to higher adverse events (AEs; adverse drug reaction): drowsiness/dizziness compared with placebo or no intervention (low certainty).

1 finding from 1 review

Lidocaine vs disopyramide

All‐cause mortality · patients with myocardial infarction

It is very uncertain whether lidocaine changes all‐cause mortality compared with disopyramide (very low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS –lidocaine vs bupivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS –lidocaine vs bupivacaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs 2‐chloroprocaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine showed no clear difference in presence of any TNS – lidocaine vs 2‐chloroprocaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs levobupivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine may leads to lower presence of any TNS – lidocaine vs levobupivacaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs mepivacaine · adults undergoing surgery

It is very uncertain whether risk of transient neurological symptoms with spinal lidocaine changes presence of any TNS – lidocaine vs mepivacaine compared with other local anaesthetic (very low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs prilocaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS – lidocaine vs prilocaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs procaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS – lidocaine vs procaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review