Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

551 questions · 579 findings · 72 reviews · Headline outcomes only

No studies found 158 · 27.3%GRADE not reported 44 · 7.6%Very low 173 · 29.9%Low 112 · 19.3%Moderate 66 · 11.4%High 26 · 4.5%

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Motor alignment at near Change in exotropia control at near fixation, measured from baseline to 3 years using the prism and alternate cover test · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in motor alignment at near Change in exotropia control at near… compared with unilateral lateral rectus recession with medial rectus resection (moderate certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Stereoacuity at near Loss of ≥ 2 octaves near stereoacuity, measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in stereoacuity at near Loss of ≥ 2 octaves near stereoacuity, measured… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Motor alignment at distance Change in exotropia control at near fixation, measured from baseline to 3 years using the prism and alternate cover test · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in motor alignment at distance Change in exotropia control at near… compared with unilateral lateral rectus recession with medial rectus resection (moderate certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in minor adverse events Defined as any adverse event within 8 weeks of… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Quality of life measures Measured at 3 years using the IXTQ scores for children, parents, or parent proxies (i.e. parents' perception of their children's quality of life). Scores could range from 0 (worst quality of life) to 100 (best quality of l... · people with intermittent exotropia, aged 3 to < 11 years
1 finding from 1 review

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Subjective cure within 12 months · women with stress urinary incontinence

Obturator medial‐to‐lateral approach showed no clear difference in subjective cure (short term ≤ 1 year) compared with obturator lateral‐to‐medial approach (low certainty).

1 finding from 1 review

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Subjective cure (medium term, 1 to 5 years) · women with stress urinary incontinence

Obturator medial‐to‐lateral approach showed no clear difference in subjective cure (medium term, 1 to 5 years) compared with obturator lateral‐to‐medial approach (low certainty).

1 finding from 1 review

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Bladder or urethral perforation · women with stress urinary incontinence

Obturator medial‐to‐lateral approach showed no clear difference in bladder or urethral perforation compared with obturator lateral‐to‐medial approach (moderate certainty).

1 finding from 1 review

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Voiding dysfunction · women with stress urinary incontinence

Obturator medial‐to‐lateral approach probably leads to higher voiding dysfunction (short and medium term, up to 5 years) compared with obturator lateral‐to‐medial approach (moderate certainty).

1 finding from 1 review

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Denovo urgency or urgency incontinence · women with stress urinary incontinence

Obturator medial‐to‐lateral approach showed no clear difference in de novo urgency or urgency incontinence (short term, up to 12 months) compared with obturator lateral‐to‐medial approach (low certainty).

1 finding from 1 review

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Vaginal tape erosion · women with stress urinary incontinence

It is very uncertain whether obturator medial‐to‐lateral approach changes vaginal tape erosion (short and medium term, up to 5 years) compared with obturator lateral‐to‐medial approach (very low certainty).

1 finding from 1 review

Obturator medial‐to‐lateral approach vs obturator lateral‐to‐medial approach

Repeat surgery for urinary incontinence · women with stress urinary incontinence

Obturator medial‐to‐lateral approach showed no clear difference in repeat incontinence surgery (short term, up to 12 months) compared with obturator lateral‐to‐medial approach (low certainty).

2 findings from 1 review

Adenoidectomy and unilateral ventilation tube vs unilateral ventilation tube only

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and unilateral ventilation tube changes presence or persistence of OME (3 years ‐ long‐term) № of… compared with unilateral ventilation tube only (very low certainty).

1 finding from 1 review