Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

151 questions · 182 findings · 35 reviews · Tobacco Addiction

No studies found 8 · 4.4%GRADE not reported 1 · 0.5%Very low 53 · 29.1%Low 67 · 36.8%Moderate 39 · 21.4%High 14 · 7.7%

Hospital‐only intervention vs intervention that continues after hospital discharge

Pharmacotherapy + behavioural support vs neither · smoking cessation in hospitalised patients

Hospital‐only intervention leads to higher pharmacotherapy + behavioural support vs neither compared with intervention that continues after hospital discharge (high certainty).

1 finding from 1 review

Telephone quitline referral vs usual care or no treatment

Health system telephone counselling vs quitline · smoking cessation in hospitalised patients

It is very uncertain whether telephone quitline referral changes health system telephone counselling vs quitline compared with no treatment or usual care (very low certainty).

1 finding from 1 review

Pharmacotherapy plus counselling vs no pharmacotherapy or placebo plus counselling

Quit at longest · smoking cessation in hospitalised patients

Pharmacotherapy plus counselling leads to higher quit at longest compared with no pharmacotherapy or placebo plus counselling (high certainty).

3 findings from 1 review

Hospital‐only intervention vs intervention that continues after hospital discharge

Behavioural support ‐ asynchronous** · smoking cessation in hospitalised patients

It is very uncertain whether hospital‐only intervention changes behavioural support ‐ asynchronous** compared with intervention that continues after hospital discharge (very low certainty).

1 finding from 1 review

Hospital‐only intervention vs intervention that continues after hospital discharge

Behavioural support ‐ synchronous** · smoking cessation in hospitalised patients

Hospital‐only intervention showed no clear difference in behavioural support ‐ synchronous** compared with intervention that continues after hospital discharge (low certainty).

1 finding from 1 review

Intervention not reported

Face‐to‐face behavioral intervention vs minimal or no support (Measured 3 to 6 months with CO‐validated prolonged and continuous abstinence, and self‐reported abstinence) · people who use waterpipe

The intervention may leads to higher face‐to‐face behavioral intervention vs minimal or no support… (low certainty).

1 finding from 1 review

Intervention not reported

Varenicline plus behavioral intervention vs placebo plus behavioral intervention ‐ (repeated point prevalence abstinence (not even a puff/chew/session in the last 7 days) at each of weeks 5, 12, and 25 (combined), verified by CO cutoff < 10 ppm) · people who use waterpipe

The intervention showed no clear difference in varenicline plus behavioral intervention vs placebo plus behavioral… (low certainty).

1 finding from 1 review

Intervention not reported

Bupropion therapy plus behavioral intervention vs behavioral intervention alone (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe

It is very uncertain whether the intervention changes bupropion therapy plus behavioral intervention vs behavioral… (very low certainty).

1 finding from 1 review

Intervention not reported

Bupropion therapy plus behavioral support versus self‐help (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe

It is very uncertain whether the intervention changes bupropion therapy plus behavioral support versus self‐help… (very low certainty).

1 finding from 1 review

Nicotine replacement therapy vs placebo

Change in weight (kg) · People who have quit smoking

Nicotine replacement therapy for smoking cessation showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (moderate certainty).

3 findings from 1 review

Varenicline vs placebo

Change in weight (kg) · People who have quit smoking

Varenicline for smoking cessation showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (high certainty).

3 findings from 1 review

Fluoexetine vs placebo

Change in weight (kg) · People who have quit smoking

Fluoexetine showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (low certainty).

2 findings from 1 review

Nicotine replacement therapy vs control

Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) · Pregnant women who smoke

Nicotine replacement therapy may leads to higher biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

1 finding from 1 review

Bupropion vs control

Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) · Pregnant women who smoke

Bupropion showed no clear difference in biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

1 finding from 1 review