Findings

What do systematic reviews say?

80 questions · 80 findings · 11 reviews · Gynaecology and Fertility

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No studies found 8 · 10%GRADE not reported 1 · 1.3%Very low 25 · 31.3%Low 35 · 43.8%Moderate 11 · 13.8%High 0 · 0%

ORT‐based algorithm vs standard dose of FSH

OHSS · Women undergoing IVF/ICSI cycles

ORT‐based algorithm showed no clear difference in OHSS compared with standard starting dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 0.74 [0.42, 1.28]
5 studies · 2724 participants
Low

ORT‐based algorithm vs standard dose of FSH

Clinical pregnancy · Women undergoing IVF/ICSI cycles

ORT‐based algorithm showed no clear difference in clinical pregnancy compared with standard starting dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 1.04 [0.91, 1.18]
7 studies · 4400 participants
Low

Anticipated low‐responders: higher vs lower dose of FSH

300/450 IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in 300/450 IU vs 150 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 1.2 [0.78, 1.86]
3 studies · 538 participants
Low

Anticipated low‐responders: higher vs lower dose of FSH

400/450 IU vs 300 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in 400/450 IU vs 300 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 0.77 [0.19, 3.19]
1 study · 62 participants
Low

Anticipated low‐responders: higher vs lower dose of FSH

IU vs 450 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in IU vs 450 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 1.33 [0.71, 2.52]
1 study · 356 participants
Low

Anticipated normal responders: higher vs lower dose of FSH

IU vs 100 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure

Anticipated normal responders: higher showed no clear difference in IU vs 100 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 0.88 [0.57, 1.36]
2 studies · 522 participants
Low

Anticipated normal responders: higher vs lower dose of FSH

225/200 IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure

Anticipated normal responders: higher showed no clear difference in 225/200 IU vs 150 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 0.98 [0.7, 1.36]
2 studies · 686 participants
Low

Anticipated normal responders: higher vs lower dose of FSH

IU vs 225 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure

Anticipated normal responders: higher showed no clear difference in IU vs 225 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 0.65 [0.32, 1.32]
1 study · 135 participants
Low

Summary of findings table ‐ ICSI vs c‐IVF

Live birth · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in live Birth compared with c‐IVF (low certainty).

1 finding from 1 review

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
RR 1.11 [0.94, 1.3]
2 studies · 1124 participants
Low

Summary of findings table ‐ ICSI vs c‐IVF

Multiple pregnancy · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in multiple Pregnancy compared with c‐IVF (moderate certainty).

1 finding from 1 review

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
RR 0.89 [0.66, 1.2]
2 studies · 1479 participants
Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Ectopic pregnancy · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in ectopic Pregnancy compared with c‐IVF (moderate certainty).

1 finding from 1 review

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
RR 1 [0.42, 2.38]
1 study · 1064 participants
Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Pre‐eclampsia · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in pre‐Eclampsia compared with c‐IVF (moderate certainty).

1 finding from 1 review

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
RR 1 [0.06, 15.95]
1 study · 1064 participants
Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Prematurity · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in prematurity compared with c‐IVF (moderate certainty).

1 finding from 1 review

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
RR 0.75 [0.53, 1.06]
1 study · 1064 participants
Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Clinical pregnancy · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in clinical Pregnancy compared with c‐IVF (low certainty).

1 finding from 1 review

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
RR 1 [0.88, 1.13]
3 studies · 1539 participants
Low

Summary of findings table ‐ ICSI vs c‐IVF

Viable intrauterine Pregnancy · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in viable intrauterine Pregnancy compared with c‐IVF (moderate certainty).

1 finding from 1 review

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
RR 1 [0.86, 1.16]
2 studies · 1479 participants
Moderate

Summary of findings table ‐ ICSI vs c‐IVF

Miscarriage · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in miscarriage compared with c‐IVF (moderate certainty).

1 finding from 1 review

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with… 2023 · Cochrane Headline outcomes only
RR 0.96 [0.58, 1.61]
1 study · 1064 participants
Moderate

Assisted hatching vs no assisted hatching

Live birth rate per woman · women undergoing assisted reproduction

Assisted hatching showed no clear difference in live births per woman randomised compared with no assisted hatching (low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.09 [0.92, 1.29]
14 studies · 2849 participants
Low

Assisted hatching vs no assisted hatching

Multiple pregnancy rate · women undergoing assisted reproduction

Assisted hatching may leads to higher multiple pregnancy rate per woman randomised compared with no assisted hatching (low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.38 [1.13, 1.68]
18 studies · 4308 participants
Low

Assisted hatching vs no assisted hatching

Clinical pregnancy rate · women undergoing assisted reproduction

Assisted hatching may leads to higher clinical pregnancy rate per woman randomised compared with no assisted hatching (low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.2 [1.09, 1.33]
39 studies · 7249 participants
Low

Assisted hatching vs no assisted hatching

Miscarriage · women undergoing assisted reproduction

It is very uncertain whether assisted hatching changes miscarriage rate per woman randomised compared with no assisted hatching (very low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.13 [0.82, 1.56]
17 studies · 2810 participants
Very low