Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

72 questions · 85 findings · 13 reviews · Pain, Palliative and Supportive Care

No studies found 11 · 12.9%GRADE not reported 0 · 0%Very low 32 · 37.6%Low 33 · 38.8%Moderate 9 · 10.6%High 0 · 0%

Tramadol vs morphine

Additional analgesia required (escape analgesia) · children undergoing surgery

Tramadol showed no clear difference in number of patients requiring rescue analgesia (PACU) compared with morphine (low certainty).

2 findings from 1 review

Tramadol vs morphine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Nalbuphine vs morphine

Number of patients with postoperative nausea and vomiting (postoperative care unit) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting… compared with morphine (low certainty).

1 finding from 1 review

Nalbuphine vs morphine

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with postoperative nausea and vomiting (24 hours… compared with morphine (low certainty).

1 finding from 1 review

Nalbuphine vs morphine

Number of patients with moderate/severe pain (1 hour postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with moderate/severe pain (1 hour postoperatively) compared with morphine (low certainty).

2 findings from 1 review

Nalbuphine vs morphine

Number of patients with the need for rescue analgesia (12 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with the need for rescue analgesia (12 hours… compared with morphine (low certainty).

1 finding from 1 review