Adverse events · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
1 finding from 1 review
Change in decayed, missing and filled (DMF/dmf) figures at surface, tooth and whole mouth level · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
The review found no eligible studies for this question.
1 finding from 1 review
Material deficiency (retention/adaptation loss; re-treatment) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
1 finding from 1 review
Proposed inhibition of S. mutans adhesion to tooth surface (mechanism; direct adherence endpoint confirmed only in Ahn 2018) · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro
Postbiotics inhibit S. mutans adhesion to tooth surfaces in vitro (ungraded narrative synthesis).
1 finding from 1 review
Virulence-gene expression related to adhesion acid production and exopolysaccharide synthesis · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro
No meta-analysis was conducted; the narrative synthesis reported reduced expression of Streptococcus mutans virulence genes.
1 finding from 1 review
Cariogenic and commensal oral bacteria (S. mutans and commensal streptococci growth, adhesion, biofilm) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…
Most in vitro studies indicate e-cigarette aerosol/e-liquid (especially flavored/high-concentration) disrupts normal oral flora and favors cariogenic S. mutans growth and biofilm, plausibly increasing caries risk; not pooled (ungraded, narrative).
1 finding from 1 review
Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)
Grape seed extract inhibits S. mutans adhesion to hydroxyapatite in vitro (2 studies; ungraded).
1 finding from 1 review
Bacterial adhesion or initial colonization · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; three included studies reported reduced adhesion or initial colonization with cranberry extract or fractions.
1 finding from 1 review
no estimate extracted
3 studies
GRADE not reported
Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)
Cranberry extract inhibits S. mutans adhesion / initial colonization in vitro (3 studies; ungraded).
1 finding from 1 review
Bacterial adhesion · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; two included studies reported reduced Streptococcus mutans adhesion with grape seed extract or fractions.
1 finding from 1 review
no estimate extracted
2 studies
GRADE not reported
Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) · Adolescents (10-19 years)
Malocclusion (DAI) probably increases the prevalence of impaired OHRQoL (CPQ 11-14) by about 15% in adolescents (RR/PR 1.15, 95% CI 1.12-1.18; moderate certainty).
1 finding from 1 review
Salivary flow rate · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
Across 19 studies the effect of gum chewing on stimulated and/or unstimulated salivary flow rate was mixed (9 positive, 10 no effect); this broad outcome was not meta-analyzed.
1 finding from 1 review
The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised subjects: a… 2023 All outcomesVarious (single session to 12 months) · Haemodialysis units, elderly / geriatric care, cancer and palliative care, and xerostomia / hyposalivation clinics (studies from multiple countries)
Narrative vote-count: of 19 studies measuring stimulated and/or unstimulated saliva flow rate, 9 found a positive effect of gum chewing [17,18,22,24,27,35,36,38,39] and 10 detected no effect…
19 studies
GRADE not reported
Poor oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Malocclusions probably have a negative effect on OHRQoL in adolescents, after adjustment for confounders (moderate certainty).
1 finding from 1 review
Impaired OHRQoL, qualitative synthesis: relative effect not estimable across the 13 studies (13,864 participants); moderate quality of evidence (GRADE).
13 studies · 13864 participants
Moderate
Need for anaesthesia · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) led to lower need for anaesthesia compared with conventional mechanical caries removal (standard drill; handpiece…; GRADE not reported.
2 findings from 1 review
Requirement for general anaesthesia due to dental procedures for caries · general population
The review found no eligible studies for this question.
1 finding from 1 review
Behavioural outcomes (reported and/or other measures, e.g. data tracking toothbrushes and collecting food wrappers) · Children aged 4 to 12 years attending primary school
The review found no eligible studies for this question.
1 finding from 1 review
Enamel surface microhardness · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, a nano-hydroxyapatite-containing orthodontic composite showed significant enamel remineralization versus control in a single study (ungraded).
1 finding from 1 review
Streptococcus mutans count · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
The antibacterial (S. mutans) effect of TiO2 nanoparticles was conflicting across two RCTs (ungraded).
1 finding from 1 review
First-time bracket failure · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Resin-modified glass ionomer cement showed no difference in first-time bracket failure, with certainty not graded.
1 finding from 1 review
No differences were observed in the proportions of patients experiencing first-time bracket failures when participants were bonded with either resin adhesive or RM-GIC (p > 0.05).
1 study · 197 participants
GRADE not reported
Streptococcus mutans count · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Chitosan and TiO2 adhesive reduced S. mutans counts, with certainty not graded.
1 finding from 1 review
Experimental group: significant decrease in S. mutans count was observed at the time points of 1 day, 2 months, and 6 months for both maxillary lateral incisor (p = 0.01) and maxillary second premolar teeth (p = 0.001).
1 study · 24 participants
GRADE not reported