Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

85 questions · 85 findings · 15 reviews · Headline outcomes only

No studies found 18 · 21.2%GRADE not reported 0 · 0%Very low 28 · 32.9%Low 19 · 22.4%Moderate 17 · 20%High 3 · 3.5%

Pregabalin or Gabapentin vs control or placebo medications

Adverse event nausea and vomiting (0 to 24 hours) · adults undergoing brain surgery

Pregabalin or Gabapentin may leads to lower adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment: methadone versus methadone plus gabapentin · management of opium withdrawal

Pharmacological detoxification treatment showed no clear difference in completion of treatment: methadone versus methadone plus gabapentin compared with other pharmacological detoxification treatment (low certainty).

1 finding from 1 review