Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 94 findings · 25 reviews

No studies found 5 · 5.3%GRADE not reported 15 · 16%Very low 27 · 28.7%Low 20 · 21.3%Moderate 17 · 18.1%High 10 · 10.6%

Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment)

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for all-cause mortality (11 studies, I2=89%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

3 findings from 1 review

Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment)

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for ACVD-related events (13 studies, I2=75%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

3 findings from 1 review

Low socioeconomic position and adverse behavioural factors vs Higher socioeconomic position and fewer adverse behaviours

Systemic inflammation (C-reactive protein) and periodontal disease progression · General-population adults (German cohort)

In one 5-year longitudinal study, accumulation of low socioeconomic and behavioural factors was associated with greater periodontal disease progression and higher C-reactive protein; not pooled (ungraded).

1 finding from 1 review

Intervention not reported

Death · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in death (low certainty).

1 finding from 1 review

Intervention not reported

Anticoagulants: events ‐ bleeding · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in anticoagulants: events ‐ bleeding (low certainty).

1 finding from 1 review

Intervention not reported

Anticoagulants: events ‐ thromboembolism · patients with leading to fewer clinical adverse events

It is very uncertain whether the intervention changes anticoagulants: events ‐ thromboembolism (very low certainty).

1 finding from 1 review

Intervention not reported

Insulin ‐ hypoglycaemia (< 60 mg/dL) · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in insulin ‐ hypoglycaemia (< 60 mg/dL) (low certainty).

1 finding from 1 review

Intervention not reported

Insulin ‐ severe hypoglycaemia (< 40 mg/dL) · patients with leading to fewer clinical adverse events

It is very uncertain whether the intervention changes insulin ‐ severe hypoglycaemia (< 40 mg/dL) (very low certainty).

1 finding from 1 review