Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

106 questions · 106 findings · 19 reviews

No studies found 16 · 15.1%GRADE not reported 9 · 8.5%Very low 22 · 20.8%Low 25 · 23.6%Moderate 25 · 23.6%High 9 · 8.5%

Combined spinal‐epidural vs high‐dose spinal

Number of women requiring supplemental intra‐operative analgesia at any time after CSE or spinal anaesthetic insertion · women undergoing caesarean section

It is very uncertain whether combined spinal‐epidural changes number of women requiring supplemental intra‐operative analgesia at… compared with high‐dose spinal (very low certainty).

1 finding from 1 review

Combined spinal‐epidural vs low‐dose spinal

Number of women requiring supplemental intra‐operative analgesia at any time after CSE or spinal anaesthetic insertion · women undergoing caesarean section

Combined spinal‐epidural showed no clear difference in number of women requiring supplemental intra‐operative analgesia at… compared with low‐dose spinal (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Regional analgesia (epidural/spinal) · childbearing women and their infants (all) (important/secondary outcomes)

It is very uncertain whether summary of findings table ‐ Midwife continuity of care models changes regional analgesia (epidural/spinal) compared with other models of care (very low certainty).

1 finding from 1 review

IM pethidine vs placebo

Additional analgesia required (epidural, pethidine and Entonox) · women in labour

IM pethidine may leads to lower additional analgesia required (epidural, pethidine and Entonox) compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Maternal satisfaction with analgesia, maternal pain score or pain measured in labour, additional analgesia, epidural

The review found no eligible studies for this question.

1 finding from 1 review

Discontinued intravenous (IV) oxytocin stimulation vs continued IV oxytocin stimulation

Use of analgesia and epidural during labour · pregnant women in latent phase of labour stimulated with oxytocin for with induction of labour. No exclusion criteria were applied in…

Discontinued intravenous (IV) oxytocin stimulation may leads to higher use of analgesia and epidural during labour compared with continued IV oxytocin stimulation (low certainty).

1 finding from 1 review

Thoracic epidural anaesthesia vs conventional pain control

Persistent pain 3 to 18 months after thoracotomy (We defined persistent postsurgical pain as new pain that did not exist before the operation, measured using differences in scores based on validated pain scales; patient interview between 3 to 18 m... · Patients undergoing thoracotomy

Thoracic epidural anaesthesia probably leads to lower persistent pain 3 to 18 months after thoracotomy (We defined… compared with conventional pain control (moderate certainty).

1 finding from 1 review

Automated mandatory bolus vs basal infusion

Breakthrough pain · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia

Automated mandatory bolus probably leads to lower breakthrough pain compared with basal infusion (moderate certainty).

1 finding from 1 review