Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

100 questions · 105 findings · 18 reviews

No studies found 18 · 17.1%GRADE not reported 8 · 7.6%Very low 20 · 19%Low 34 · 32.4%Moderate 18 · 17.1%High 7 · 6.7%

Chemotherapy vs chemotherapy alone

Overall survival (taxane‐containing doublet therapy vs taxane monotherapy) · advanced gastric adenocarcinoma

Chemotherapy showed no clear difference in overall survival (taxane‐containing doublet therapy vs taxane… compared with chemotherapy (low certainty).

1 finding from 1 review

Chemotherapy vs chemotherapy alone

Tumour response rate (taxane‐containing doublet therapy vs taxane monotherapy) · advanced gastric adenocarcinoma

It is very uncertain whether chemotherapy changes tumour response rate (taxane‐containing doublet therapy vs taxane… compared with chemotherapy (very low certainty).

1 finding from 1 review

Intervention not reported

Sleep onset latency Participant reports. Scale from 30 to 540 minutes; fewer minutes equalled better outcome; CFB and double‐blind average values included · Patients with insomnia
1 finding from 1 review
  • Eszopiclone for insomnia 2018 · Cochrane Headline outcomes only
    no estimate extracted
    9 studies · 2890 participants
    Moderate

Intervention not reported

Wake time after sleep onset Participant reports. Scale from: 30 to 540 minutes; fewer minutes equalled better outcome; CFB and double‐blind average values included · Patients with insomnia
1 finding from 1 review
  • Eszopiclone for insomnia 2018 · Cochrane Headline outcomes only
    no estimate extracted
    8 studies · 2295 participants
    Moderate

Intervention not reported

Total sleep time Participant reports. Scale from: 300 to 840; more minutes equalled better outcome; CFB and double‐blind average values included · Patients with insomnia
1 finding from 1 review
  • Eszopiclone for insomnia 2018 · Cochrane Headline outcomes only
    no estimate extracted
    9 studies · 2935 participants
    Moderate

Intervention not reported

Next‐day alertness Participant reports. Scale from: 0 to 10 points; higher scores equalled better outcome; CFB and double‐blind average values included · Patients with insomnia
1 finding from 1 review

Intervention not reported

Serious adverse events (as defined in the primary study) Participant reports. Serious adverse events observed during double‐blind treatment period · Patients with insomnia
1 finding from 1 review
  • Eszopiclone for insomnia 2018 · Cochrane Headline outcomes only
    no estimate extracted
    12 studies · 4289 participants
    Moderate

Intervention not reported

Lack of efficacy withdrawal in randomised double‐blind phase · Adults with chronic neuropathic pain
1 finding from 1 review

Intervention not reported

Adverse event withdrawal in randomised double‐blind phase · Adults with chronic neuropathic pain
1 finding from 1 review

COMPARISON 1. ARIPIPRAZOLE vs placebo

Numbers completing double‐blind treatment Number of participants · patients with an acute manic or mixed episode

Aripiprazole showed no clear difference in numbers completing double‐blind treatment Number of participants compared with placebo (moderate certainty).

1 finding from 1 review

Multiple vs double‐injection technique

Secondary analgesia failure: Intraoperative sedation required · Adult patients undergoing hand, wrist or forearm surgery

Multiple showed no clear difference in secondary analgesia failure ‐ intraoperative sedation required compared with double‐injection technique (high certainty).

1 finding from 1 review

Multiple vs double‐injection technique

Secondary analgesia failure : Tourniquet pain · Adult patients undergoing hand, wrist or forearm surgery

Multiple leads to lower secondary analgesia failure ‐ tourniquet pain compared with double‐injection technique (high certainty).

1 finding from 1 review