Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

445 questions · 449 findings · 45 reviews · Airways

No studies found 35 · 7.8%GRADE not reported 26 · 5.8%Very low 30 · 6.7%Low 134 · 29.8%Moderate 160 · 35.6%High 64 · 14.3%

Intervention not reported

Number of participants requiring oral corticosteroids over the study period · Adults from minority groups with doctor diagnosed asthma

It is very uncertain whether the intervention changes number of participants requiring oral corticosteroids over the study… (very low certainty).

1 finding from 1 review

Intervention not reported

Exacerbations requiring oral corticosteroids 7.3‐month · people with asthma

The intervention showed no clear difference in exacerbations requiring oral corticosteroids 7.3‐month (low certainty).

1 finding from 1 review

Intervention not reported

Exacerbations requiring oral corticosteroids3 months · adults or children with asthma

The intervention showed no clear difference in exacerbations requiring oral corticosteroids3 months (low certainty).

1 finding from 1 review

Intermittent ICS vs placebo

Exacerbations requiring oral corticosteroids ‐ School‐age children · School‐aged children and adults

Intermittent ICS showed no clear difference in exacerbations requiring oral corticosteroids ‐ School‐age children compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Asthma exacerbation as defined by hospital admission or treatment with a course of oral corticosteroids · participants with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Asthma exacerbation as defined by hospital admission or treatment with a course of oral corticosteroids · participants with exercise‐induced asthma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Exacerbations requiring a course of oral corticosteroids · children and adolescents aged 18 years and under studies with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Formoterol vs short‐acting beta2‐agonist

Exacerbations requiring oral corticosteroids ‐ adults · people with asthma

Formoterol probably leads to lower patients with an exacerbation requiring a course of oral… compared with short‐acting beta2‐agonist (moderate certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Unscheduled physician visits 44 weeks · adults and children with chronic asthma

Increased showed no clear difference in unscheduled physician visits 44 weeks compared with stable doses of inhaled corticosteroids (low certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Serious adverse events 48 weeks · adults and children with chronic asthma

It is very uncertain whether increased changes serious adverse events 48 weeks compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Non‐serious adverse events 43 weeks · adults and children with chronic asthma

It is very uncertain whether increased changes non‐serious adverse events 43 weeks compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review