Findings

What do systematic reviews say?

864 questions · 895 findings · 140 reviews · Headline outcomes only

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No studies found 202 · 22.6%GRADE not reported 53 · 5.9%Very low 227 · 25.4%Low 254 · 28.4%Moderate 131 · 14.6%High 28 · 3.1%

Continuous infusion vs bolus administration

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · postoperative pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs bolus administration

Severe (grade 3 or greater) intraventricular hemorrhage (IVH) on cranial ultrasound ‐ not reported · postoperative pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Systemic opioid regimens for postoperative pain in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

30‐Day amputation‐free survival · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Amputation · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 164 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

30‐Day mortality · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Vessel patency (up to 30 days) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Duration of thrombolysis (to end of treatment) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Stroke · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

Major bleeding · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 304 participants
Very low

Continuous positive airway pressure (CPAP) vs supportive treatment

Incidence of mechanical ventilation · children with acute bronchiolitis

Continuous positive airway pressure (CPAP) showed no clear difference in proportion of children requiring mechanical ventilation compared with supportive treatment (low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) for acute bronchiolitis in children 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 122 participants
Low

Continuous positive airway pressure (CPAP) vs supportive treatment

Time to recovery · children with acute bronchiolitis

1 finding from 1 review

Continuous positive airway pressure (CPAP) for acute bronchiolitis in children 2022 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Continuous positive airway pressure (CPAP) vs supportive treatment

Change in respiratory rate at 20 minutes · children with acute bronchiolitis

Continuous positive airway pressure (CPAP) showed no clear difference in mean change in respiratory rate (breaths/min) compared with supportive treatment (low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) for acute bronchiolitis in children 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 91 participants
Low

Continuous positive airway pressure (CPAP) vs supportive treatment

Adverse effects · children with acute bronchiolitis

1 finding from 1 review

Continuous positive airway pressure (CPAP) for acute bronchiolitis in children 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 72 participants
GRADE not reported

Continuous local anaesthetic wound infusion vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults undergoing elective midline laparotomy for colorectal resection

1 finding from 1 review

Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 511 participants
High

Continuous local anaesthetic wound infusion vs placebo

Pain (VAS scores) on movement at postoperative day 1 Scale from: 0 to 10. · adults undergoing elective midline laparotomy for colorectal resection

1 finding from 1 review

Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 407 participants
Low

Continuous local anaesthetic wound infusion vs placebo

Opioid consumption via patient controlled analgesia postoperative day 1 · adults undergoing elective midline laparotomy for colorectal resection

1 finding from 1 review

Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 528 participants
Moderate

Continuous local anaesthetic wound infusion vs placebo

Time to first BM (№ women with 1st BM on day 2 after delivery) · adults undergoing elective midline laparotomy for colorectal resection

1 finding from 1 review

Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 197 participants
Moderate

Continuous local anaesthetic wound infusion vs placebo

Length of hospital stay · adults undergoing elective midline laparotomy for colorectal resection

1 finding from 1 review

Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 456 participants
High

Continuous local anaesthetic wound infusion vs placebo

Any serious postoperative adverse event (until hospital discharge) · adults undergoing elective midline laparotomy for colorectal resection

Continuous local anaesthetic wound infusion showed no clear difference in any serious postoperative adverse event (until hospital discharge) compared with placebo (low certainty).

1 finding from 1 review

Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection… 2019 · Cochrane Headline outcomes only
RR 1.04 [0.68, 1.58]
6 studies · 541 participants
Low

Continuous veno‐venous hemofiltration (CVVH) vs no CVVH

All‐cause mortality · adults with severe acute pancreatitis

1 finding from 1 review

Continuous veno‐venous hemofiltration for severe acute pancreatitis 2019 · Cochrane Headline outcomes only
0.62 [0.27, 1.4]
2 studies · 189 participants
Very low