Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

335 questions · 406 findings · 23 reviews

No studies found 93 · 22.9%GRADE not reported 166 · 40.9%Very low 66 · 16.3%Low 65 · 16%Moderate 14 · 3.4%High 2 · 0.5%

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride mouthrinse

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less
1 finding from 1 review

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride toothpaste alone

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less
1 finding from 1 review

CarieScan Pro device vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
1 finding from 1 review
  • Electrical conductance for the detection of dental caries 2021 · Cochrane All outcomes
    Up to 3 months between index test and reference standard (in vivo studies)
    CarieScan Pro (3 studies, 244 tooth surfaces): sensitivity ranged from 0.55 to 0.91. No evidence of a difference in accuracy by device type (Chi2=0.05, df=1, P=0.82).
    3 studies
    GRADE not reported

CarieScan Pro device vs Reference standard (histology, excavation, or enhanced visual examination)

Specificity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
1 finding from 1 review

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Dental pain or sensitivity · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes dental pain or sensitivity compared with atraumatic restorative treatment (ART) with glass ionomer cement… (very low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations)

Caries arrest · Children and adults (with or without carious lesions)

Silver diamine fluoride (SDF) plus fluoride varnish showed no clear difference in caries arrest compared with sealants plus fluoride varnish (with or without restorations) (low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Secondary prevention of caries · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

1 finding from 1 review

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Primary caries prevention · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

1 finding from 1 review

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Caries arrest · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

2 findings from 1 review

Xylitol sucking tablets (1 g/day) vs no treatment

Number of infants with a caries increment · Infants/young children (primary teeth; baseline about 1 to 3 years)

Xylitol sucking tablets (1 g/day) showed no clear difference in number of infants with a caries increment compared with no treatment; GRADE not reported.

1 finding from 1 review

Chlorhexidine varnish (10% and 40%) vs placebo or no treatment

Caries increment in permanent teeth · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

It is very uncertain whether chlorhexidine varnish (10% and 40%) changes caries increment in permanent dentition (DMFS; higher values… compared with placebo or no treatment (very low certainty).

1 finding from 1 review