Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

136 questions · 139 findings · 26 reviews

No studies found 12 · 8.6%GRADE not reported 25 · 18%Very low 36 · 25.9%Low 43 · 30.9%Moderate 19 · 13.7%High 4 · 2.9%

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Mother to Child Transmission Late Postpartum Negative HIV DNA PCR at Birth and One Month, But Positive HIV DNA PCR at Six Months · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

Mma Bana continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission Late Postpartum Negative HIV DNA PCR at… compared with AZT/3TC/ABC (low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Mother to Child Transmission at 6 Weeks · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

Mma Bana continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission at Six Months Post‐Partum All Positive… compared with AZT/3TC/ABC (low certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs AZT (+/‐ single dose NVP)

HIV‐Transmission or Death at 7 Months · HIV‐infected pregnant women with CD4 Counts <200 cells/mm31

It is very uncertain whether bae: AZT/3TC/NVP changes HIV‐Transmission or Death at 7 Months compared with AZT (+/‐ single dose NVP) (very low certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs AZT (+/‐ single dose NVP)

Infant Grade 3/4 Severe Adverse Events at Birth · HIV‐infected pregnant women with CD4 Counts <200 cells/mm31

It is very uncertain whether bae: AZT/3TC/NVP changes infant Grade 3/4 Severe Adverse Events at Birth compared with AZT (+/‐ single dose NVP) (very low certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs AZT (+/‐ single dose NVP)

Mother to Child Transmission at Birth · HIV‐infected pregnant women with CD4 Counts <200 cells/mm31

It is very uncertain whether bae: AZT/3TC/NVP changes mother to Child Transmission at Birth compared with AZT (+/‐ single dose NVP) (very low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant Mortality at 6 Months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora: AZT/3TC/LPV‐r showed no clear difference in infant Mortality at 6 Months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (moderate certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs AZT (+/‐ single dose NVP)

Mother to Child Transmission at 1 Month · HIV‐infected pregnant women with CD4 Counts <200 cells/mm31

It is very uncertain whether bae: AZT/3TC/NVP changes mother to Child Transmission at 1 Month compared with AZT (+/‐ single dose NVP) (very low certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs AZT (+/‐ single dose NVP)

Mother to Child Transmission Cumulative by 7 Months · HIV‐infected pregnant women with CD4 Counts <200 cells/mm31

It is very uncertain whether bae: AZT/3TC/NVP changes mother to Child Transmission Cumulative by 7 Months compared with AZT (+/‐ single dose NVP) (very low certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs >250 cells/mm3

Hepatotoxicity:13 Grade 3 and 4 toxicity · HIV‐infected pregnant women

Marazzi: AZT/3TC/NVP for HIV Infection in Pregnant Women With CD4 <250 showed no clear difference in maternal Grade 3/4 Hepatotoxicity compared with >250 cells/mm3; GRADE not reported.

1 finding from 1 review

Bae: AZT/3TC/NVP vs AZT/3TC/NVP

Maternal Grade 3/4 Severe Adverse Events · HIV‐1 Infected Pregnant Women Who Have CD4>200 Compared with Those Who Have CD4<200 Cells/mm3

It is very uncertain whether phanuphak: AZT/3TC/NVP (PMTCT) changes maternal Grade 3/4 Severe Adverse Events compared with AZT/3TC/NVP (ART) (very low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant Mortality at 12 months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora: AZT/3TC/LPV‐r showed no clear difference in infant Mortality at 12 months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Maternal Grade 3/4 Severe Adverse Events · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

It is very uncertain whether kesho Bora: AZT/3TC/LPV‐r changes maternal Grade 3/4 Severe Adverse Events compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (very low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant Grade 3/4 Severe Adverse Events · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora: AZT/3TC/LPV‐r showed no clear difference in infant Grade 3/4 Severe Adverse Events compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Prematurity · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

It is very uncertain whether kesho Bora: AZT/3TC/LPV‐r changes prematurity compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (very low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Low birthweight · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora continued: AZT/3TC/LPV‐r showed no clear difference in low Birth Weight compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Stillbirth · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora continued: AZT/3TC/LPV‐r showed no clear difference in stillbirths compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Death during study period · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in all‐cause mortality (prophylactic trials) (over duration of trial) compared with control/placebo (low certainty).

2 findings from 1 review