Bae: AZT/3TC/NVP vs >250 cells/mm3: Hepatotoxicity:13 Grade 3 and 4 toxicity
Marazzi: AZT/3TC/NVP for HIV Infection in Pregnant Women With CD4 <250 showed no clear difference in maternal Grade 3/4 Hepatotoxicity compared with >250 cells/mm3; GRADE not reported.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Marazzi: AZT/3TC/NVP for HIV Infection in Pregnant Women With CD4 <250 vs >250 cells/mm3 Maternal Grade 3/4 Hepatotoxicity · HIV‐infected Pregnant Women Marazzi: AZT/3TC/NVP for HIV Infection in Pregnant Women With CD4 <250 showed no clear difference in maternal Grade 3/4 Hepatotoxicity compared with >250 cells/mm3; GRADE not reported. Antiretroviral therapy (ART) for treating HIV infection in ART‐eligible pregnant women (2010) · Cochrane Headline outcomes only | RR 0.64 [0.34, 1.2] | 1 study · 703 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiretroviral therapy (ART) for treating HIV infection in ART‐eligible pregnant women 2010 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.