Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

175 questions · 179 findings · 20 reviews

No studies found 14 · 7.8%GRADE not reported 1 · 0.6%Very low 29 · 16.2%Low 81 · 45.3%Moderate 41 · 22.9%High 13 · 7.3%

Perioperative beta‐blockers vs placebo or usual care

Ventricular arrhythmias (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

It is very uncertain whether perioperative beta‐blockers changes ventricular arrhythmias (within 30 days) compared with placebo or standard care (very low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Atrial fibrillation or atrial flutter, or both (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers may leads to lower atrial fibrillation or atrial flutter, or both (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Bradycardia · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers may leads to higher bradycardia (within 30 days; as defined by study authors, minimum… compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Hypotension · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers probably leads to higher hypotension (within 30 days; as defined by study authors, minimum… compared with placebo or standard care (moderate certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Rescue treatment with anti‐VEGF agents · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers may leads to lower rescue treatment with anti‐VEGF agents compared with placebo or no treatment (low certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Treatment with laser photocoagulation or cryotherapy · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers may leads to lower treatment with laser photocoagulation or cryotherapy compared with placebo or no treatment (low certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Progression to stage 2 with plus disease · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers showed no clear difference in progression to stage 2 with plus disease compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Progression to stage 3 ROP · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers probably leads to lower progression to stage 3 ROP compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Progression to stage 4 or 5 ROP · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers showed no clear difference in progression to stage 4 or 5 ROP compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Arterial hypotension and/or bradycardia requiring treatment · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers may leads to higher arterial hypotension and/or bradycardia requiring treatment compared with placebo or no treatment (low certainty).

1 finding from 1 review