Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

175 questions · 179 findings · 20 reviews

No studies found 14 · 7.8%GRADE not reported 1 · 0.6%Very low 29 · 16.2%Low 81 · 45.3%Moderate 41 · 22.9%High 13 · 7.3%

Beta‐blockers vs placebo or no treatment

Heart failure hospitalisation (RR) · patients with chronic heart failure with preserved ejection fraction

It is very uncertain whether beta‐blockers changes heart failure hospitalisation (RR) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Beta‐blockers vs placebo or no intervention

MACE · patients with suspected or diagnosed myocardial infarction

It is very uncertain whether beta‐blockers changes MACE (major adverse cardiovascular event) at maximum compared with placebo or no intervention (very low certainty).

2 findings from 1 review

Beta‐blockers vs placebo or no intervention

Angina · patients with suspected or diagnosed myocardial infarction

It is very uncertain whether beta‐blockers changes angina at maximum compared with placebo or no intervention (very low certainty).

2 findings from 1 review

Beta‐blockers vs placebo or no intervention

Cardiovascular mortality · patients with suspected or diagnosed myocardial infarction

Beta‐blockers probably leads to lower cardiovascular mortality at maximum compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Beta‐blockers vs placebo or no intervention

Myocardial infarction · patients with suspected or diagnosed myocardial infarction

Beta‐blockers showed no clear difference in myocardial infarction at maximum compared with placebo or no intervention (low certainty).

2 findings from 1 review

Beta‐blockers vs placebo

Total mortality

Beta‐blockers showed no clear difference in total mortality compared with placebo (moderate certainty).

1 finding from 1 review

Beta‐blockers vs diuretics

Withdrawals due to adverse events

Beta‐blockers showed no clear difference in withdrawal due to adverse effect compared with diuretics (low certainty).

1 finding from 1 review