Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

271 questions · 277 findings · 30 reviews · Headline outcomes only

No studies found 31 · 11.2%GRADE not reported 10 · 3.6%Very low 93 · 33.6%Low 64 · 23.1%Moderate 65 · 23.5%High 14 · 5.1%

Topical prophylaxis vs no topical prophylaxis

Dropouts due to adverse events · adults receiving mechanical ventilation for at least 48 hours

It is very uncertain whether topical prophylaxis changes dropouts due to adverse events compared with no topical prophylaxis (very low certainty).

1 finding from 1 review

Topical prophylaxis vs no topical prophylaxis

Gastrointestinal adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical prophylaxis showed no clear difference in gastrointestinal adverse events compared with no topical prophylaxis (low certainty).

1 finding from 1 review

Topical prophylaxis vs no topical prophylaxis

Allergic adverse events · adults receiving mechanical ventilation for at least 48 hours

It is very uncertain whether topical prophylaxis changes allergic adverse events compared with no topical prophylaxis (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Total postoperative infections ‐ early and late · women having elective vaginal hysterectomy

Antibiotics may leads to lower total postoperative infections ‐ early and late compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Pelvic infection · women having elective abdominal hysterectomy

Antibiotics probably leads to lower pelvic infection compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Other serious infections · women having elective abdominal hysterectomy

It is very uncertain whether antibiotics changes other serious infections compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Postoperative fever · women having elective abdominal hysterectomy

Antibiotics probably leads to lower postoperative fever compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Total adverse effects · women having elective abdominal hysterectomy

It is very uncertain whether antibiotics changes total adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Urinary tract infection · women having elective vaginal hysterectomy

Antibiotics probably leads to lower urinary tract infection compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Other serious infections · women having elective vaginal hysterectomy

It is very uncertain whether antibiotics changes other serious infections compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Postoperative fever · women having elective vaginal hysterectomy

Antibiotics probably leads to lower postoperative fever compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Total postoperative infections ‐ early and late · women having elective abdominal hysterectomy

Antibiotics may leads to lower total postoperative infections ‐ early and late compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Abdominal surgical site infection · women having elective abdominal hysterectomy

Antibiotics probably leads to lower abdominal wound infection compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Urinary tract infection · women having elective abdominal hysterectomy

Antibiotics probably leads to lower urinary tract infection compared with placebo (moderate certainty).

1 finding from 1 review