Relapse · group A streptococcal pharyngitis
It is very uncertain whether azithromycin changes relapse (ITT analysis) compared with amoxicillin (very low certainty).
1 finding from 1 review
Relapse (bacteriological per protocol analysis) · group A streptococcal pharyngitis
It is very uncertain whether azithromycin changes relapse (bacteriological per protocol analysis) compared with amoxicillin (very low certainty).
1 finding from 1 review
Adverse events (ITT analysis) · group A streptococcal pharyngitis
It is very uncertain whether azithromycin changes adverse events (ITT analysis) compared with amoxicillin (very low certainty).
1 finding from 1 review
Clinical cure · group A streptococcal pharyngitis
It is very uncertain whether azithromycin changes clinical cure (ITT analysis) compared with amoxicillin (very low certainty).
1 finding from 1 review
Resolution of ear discharge ‐ measured at 1 to 2 weeks · adults with CSOM
It is very uncertain whether topical quinolone changes resolution of ear discharge ‐ 1 to 2 weeks compared with oral amoxicillin‐clavulanic acid combination (very low certainty).
1 finding from 1 review
Resolution of ear discharge ‐ measured after 4 weeks · adults with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life · adults with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Ear pain (otalgia) or discomfort or local irritation · adults with CSOM
1 finding from 1 review
Hearing · adults with CSOM
1 finding from 1 review
Serious complications · adults with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Suspected ototoxicity · adults with CSOM
1 finding from 1 review
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Adverse events · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.
1 finding from 1 review
All three included trials (Matarazzo 2008; Silva 2011; Xajigeorgiou 2006) reported adverse events in both MTZ + SRP and AMOX + MTZ + SRP groups (nausea, vomiting, diarrhoea, headache, metallic taste, irritability, mild…
3 studies · 84 participants
GRADE not reported
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Adverse events · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.
1 finding from 1 review
Cure of gonococcal infection (microbiological culture) · pregnant women with gonorrhoea infection
It is very uncertain whether intramuscular ceftriaxone changes cure of gonococcal infection (microbiological culture) compared with oral amoxicillin plus oral probenecid (very low certainty).
1 finding from 1 review
Incidence of obstetric complications · pregnant women with gonorrhoea infection
1 finding from 1 review