Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection
It is very uncertain whether amoxicillin changes microbiological cure compared with placebo (very low certainty).
1 finding from 1 review
Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection
It is very uncertain whether amoxicillin changes microbiological cure compared with azithromycin (very low certainty).
1 finding from 1 review
Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection
Amoxicillin showed no clear difference in microbiological cure compared with erythromycin (high certainty).
1 finding from 1 review
Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection
Amoxicillin showed no clear difference in microbiological cure compared with clindamycin (moderate certainty).
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis
It is very uncertain whether amoxicillin + clavulanate + SRP changes percentage of bleeding on probing (BOP) compared with SRP (very low certainty).
3 findings from 1 review
MD 0.00 [-0.09, 0.09]
1 study · 21 participants
Very low
MD -0.10 [-0.19, -0.01]
1 study · 21 participants
GRADE not reported
MD -0.10 [-0.19, -0.01]
1 study · 21 participants
GRADE not reported
Probing pocket depth · Adults with chronic periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.00 [-0.19, 0.19]
1 study · 21 participants
GRADE not reported
MD 0.10 [-0.17, 0.37]
1 study · 21 participants
Very low
MD 0.20 [-0.02, 0.42]
1 study · 21 participants
GRADE not reported
Adverse events · Adults with aggressive periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in adverse events compared with tetracycline + SRP; GRADE not reported.
1 finding from 1 review
Clinical attachment level (CAL) · Adults with chronic periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.10 [-0.45, 0.65]
1 study · 21 participants
GRADE not reported
MD 0.10 [-0.51, 0.71]
1 study · 21 participants
Very low
MD 0.10 [-0.43, 0.63]
1 study · 21 participants
GRADE not reported
Adverse events · Adults with chronic periodontitis
It is very uncertain whether amoxicillin + clavulanate + SRP changes adverse events compared with SRP (very low certainty).
1 finding from 1 review
Antimicrobial resistance · Adults with chronic periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of closed pockets · Adults with chronic periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with tetracycline + SRP; GRADE not reported.
1 finding from 1 review
MD -1.60 [-14.03, 10.83]
1 study · 8 participants
GRADE not reported
Patient-reported quality of life changes · Adults with chronic periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in probing pocket depth compared with tetracycline + SRP; GRADE not reported.
1 finding from 1 review
MD -0.40 [-1.11, 0.31]
1 study · 8 participants
GRADE not reported
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD -0.47 [-0.68, -0.26]
6 studies · 215 participants
GRADE not reported
MD -0.18 [-0.33, -0.04]
15 studies · 562 participants
GRADE not reported
MD -0.30 [-0.42, -0.18]
2 studies · 389 participants
Very low
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -2.05 [-2.98, -1.11]
13 studies · 460 participants
GRADE not reported
MD -5.32 [-12.02, 1.37]
5 studies · 172 participants
GRADE not reported
MD -8.06 [-14.26, -1.85]
2 studies · 389 participants
Very low
Probing pocket depth · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether amoxicillin + metronidazole + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.47 [-0.90, -0.05]
2 studies · 389 participants
Very low
MD -0.21 [-0.41, -0.01]
13 studies · 501 participants
GRADE not reported
MD -0.04 [-0.35, 0.26]
6 studies · 215 participants
GRADE not reported
Adverse events · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.
1 finding from 1 review