Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

157 questions · 158 findings · 44 reviews · Headline outcomes only

No studies found 25 · 15.8%GRADE not reported 7 · 4.4%Very low 40 · 25.3%Low 50 · 31.6%Moderate 33 · 20.9%High 3 · 1.9%

Ventilation tubes vs no treatment

Adverse event: persistent perforation · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether ventilation tubes changes adverse event: persistent perforation Randomised by ear, assumed CC… compared with no treatment (very low certainty).

1 finding from 1 review

Intranasal steroid spray vs no treatment

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether topical (intranasal) steroids changes presence/persistence of OME (short‐term); assumed ICC = 0.5 compared with no treatment (very low certainty).

1 finding from 1 review

Implementation interventions vs no intervention

HRQoL at 6 or 12 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: HRQoL (EQ‐5D: –0.59 to 1, higher score… compared with no intervention (moderate certainty).

1 finding from 1 review

Wavefront‐optimized procedures vs wavefront‐guided procedures

Eyes within ± 0.5 D of target refraction · Adults with refractive errors

Wavefront‐optimized procedures showed no clear difference in proportion of eyes within ± 0.50 diopters (D) of target refraction… compared with wavefront‐guided procedures (low certainty).

1 finding from 1 review

Wavefront‐guided LASIK vs wavefront‐guided PRK

Eyes within ± 0.5 D of target refraction · Adults with refractive errors

It is very uncertain whether wavefront‐guided LASIK changes proportion of eyes within ± 0.50 diopters (D) of target refraction… compared with wavefront‐guided PRK (very low certainty).

1 finding from 1 review

Wavefront procedures vs conventional procedures

Proportion of eyes within ± 0.50 diopters (D) of target refraction: 12 months ‐ Procedure PRK · Adults with refractive errors

Wavefront procedures showed no clear difference in proportion of eyes within ± 0.50 diopters (D) of target refraction:… compared with conventional procedures (low certainty).

1 finding from 1 review

Intervention not reported

Suicide (Observation period: pre‐intervention 30.5 years; postintervention 13.5 years) · adults or children of all ethnicities

The intervention may leads to lower suicide (Observation period: pre‐intervention 30.5 years;… (low certainty).

1 finding from 1 review

Toric intraocular lens (IOL) vs limbal relaxing incisions (LRIs)

Postoperative residual refractive astigmatism of less than 0.50 D · people with astigmatism who are having cataract surgery (phacoemulsification)

Toric intraocular lens (IOL) probably leads to higher postoperative residual refractive astigmatism of less than 0.50 D compared with limbal relaxing incisions (LRIs) (moderate certainty).

1 finding from 1 review

Higher dose vitamin K vs lower dose vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review