Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Metronidazole vs vancomycin

Cure (combined symptomatic and bacteriologic cure) ‐ mild disease · patients with Clostridium difficile‐associated diarrhoea in adults

It is very uncertain whether metronidazole changes cure (combined symptomatic and bacteriologic cure) ‐ mild disease compared with vancomycin (very low certainty).

1 finding from 1 review

Metronidazole vs vancomycin

Cure (combined symptomatic and bacteriologic cure) ‐ severe disease · patients with Clostridium difficile‐associated diarrhoea in adults

It is very uncertain whether metronidazole changes cure (combined symptomatic and bacteriologic cure) ‐ severe disease compared with vancomycin (very low certainty).

1 finding from 1 review

Dexamethasone vs placebo

Incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Dexamethasone showed no clear difference in incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival… compared with placebo (low certainty).

1 finding from 1 review

Methylphenidate vs placebo

Tic severity Measured by standardized rating scales: Yale Global Tic Severity Scale, Tourette Syndrome Severity Scale, Global Tic Rating Scale, Tic Symptom Self‐Report, Hopkins Motor/Vocal Scale · children with ADHD and comorbid tic disorders
1 finding from 1 review