Cochrane · systematic review · CD004610
Antibiotic treatment for Clostridium difficile‐associated diarrhoea in adults
Nelson, RL, Suda, KJ, Evans, CT · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 75%Low 0 · 0%Moderate 2 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsMetronidazole versus vancomycin for Clostridium difficile‐associated diarrhoea in adults
Population: patients with Clostridium difficile‐associated diarrhoea in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Symptomatic cure with all exclusions treated as failures Metronidazole vs vancomycin | RR 0.9 [0.84, 0.97] | 4 studies · 872 participants | Moderate Downgraded: risk of bias |
Bacteriologic cure Metronidazole vs vancomycin | RR 0.85 [0.62, 1.17] | 2 studies · 163 participants | Very low Downgraded: risk of bias, imprecision |
Cure (combined symptomatic and bacteriologic cure) ‐ mild disease Metronidazole vs vancomycin | RR 0.88 [0.71, 1.09] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision |
Cure (combined symptomatic and bacteriologic cure) ‐ severe disease Metronidazole vs vancomycin | RR 0.74 [0.52, 1.04] | 1 study · 82 participants | Very low Downgraded: risk of bias, imprecision |
Teicoplanin versus vancomycin for Clostridium difficile‐associated diarrhoea in adults
Population: patients with Clostridium difficile‐associated diarrhoea in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Symptomatic Cure Teicoplanin vs vancomycin | RR 1.21 [1, 1.46] | 2 studies · 110 participants | Very low Downgraded: risk of bias, imprecision |
Bacteriologic Cure Teicoplanin vs vancomycin | RR 1.82 [1.19, 2.78] | 1 study · 59 participants | Very low Downgraded: risk of bias, imprecision |
Fidaxomicin compared to vancomycin for Clostridium difficile‐associated diarrhoea in adults
Population: patients with Clostridium difficile‐associated diarrhoea in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Symptomatic Cure Fidaxomicin vs vancomycin | RR 1.17 [1.07, 1.27] | 2 studies · 1164 participants | Moderate Downgraded: risk of bias |
Bacitracin versus vancomycin for Clostridium difficile‐associated diarrhoea in adults
Population: patients with Clostridium difficile‐associated diarrhoea in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Symptomatic Cure Bacitracin vs vancomycin | RR 0.58 [0.34, 0.99] | 2 studies · 104 participants | Very low Downgraded: risk of bias, imprecision |