Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,138 questions · 1,154 findings · 139 reviews · Headline outcomes only

No studies found 184 · 15.9%GRADE not reported 183 · 15.9%Very low 273 · 23.7%Low 296 · 25.6%Moderate 171 · 14.8%High 47 · 4.1%

Intervention not reported

Appetite improvement compared to other drugs Questionnaire of appetite rating · cachexia anorexia syndrome

The intervention showed no clear difference in appetite improvement compared to other drugs Questionnaire of… (low certainty).

1 finding from 1 review

Intervention not reported

Weight improvement compared to other drugs % of patients that improved their weight in kg · cachexia anorexia syndrome

It is very uncertain whether the intervention changes weight improvement compared to other drugs % of patients that… (very low certainty).

1 finding from 1 review

Intervention not reported

Retention to treatment Number of participants who competed treatment · Amphetamine abuse or dependence

The intervention showed no clear difference in retention to treatment Number of participants who competed treatment (low certainty).

1 finding from 1 review

Gabapentin vs placebo

50% or greater reduction in seizure frequency Number of seizures · people with drug‐resistant focal epilepsy

Gabapentin probably leads to higher reduction in seizure frequency of ≥ 50%: primary analysisNumber of… compared with placebo (moderate certainty).

1 finding from 1 review

Gabapentin vs placebo

Adverse effects: ataxia Number of participants experiencing ataxia · people with drug‐resistant focal epilepsy

Gabapentin may leads to higher adverse effects: ataxiaNumber of participants experiencing ataxia compared with placebo (low certainty).

1 finding from 1 review

Moxifloxacin‐containing 4‐month ATT regimens vs standard 6‐month ATT regimen

Relapse · adults with drug‐sensitive pulmonary tuberculosis

Moxifloxacin‐containing 4‐month ATT regimens probably leads to higher relapse compared with standard 6‐month ATT regimen (moderate certainty).

1 finding from 1 review