Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Chronic herpes simplex infection (WHO clinical stage 4) · Children or adolescents

No eligible studies reported chronic herpes simplex infection.

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Persistent parotid enlargement (WHO clinical stage 2) · Children or adolescents

No significant difference in persistent parotid enlargement between groups (OR 10.36, 95% CI 0.53 to 201.45; single study, very imprecise).

1 finding from 1 review

Compomer (C) vs Amalgam, RMGIC, HVGIC, composite resin, bulk-fill composite resin, another compomer, or alternative caries management

Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years

Compomer had an annual failure rate of 0-14.7% (7 RCTs), comparable to amalgam/RMGIC/composite and better than high-viscosity GIC; low quality of evidence (ungraded).

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Oral hairy leukoplakia (WHO clinical stage 3) · Children or adolescents

No difference in oral hairy leukoplakia between groups (pooled OR 1.00, 95% CI 0.06 to 16.19); lesion essentially absent in both.

1 finding from 1 review

Summary of findings: unconditional cash transfer vs no unconditional cash transfer: primary outcomes

Engages in child labour · children (0 to 17 years) and adults (≥ 18 years) or households

It is very uncertain whether summary of findings: unconditional cash transfer changes engages in child labour compared with no unconditional cash transfer: secondary outcomes (very low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

IgE‐mediated food allergy (oral food challenge) by 1 to 3 years · infants

Skin care intervention showed no clear difference in igE‐mediated food allergy (oral food challenge) by 1 to 3 years compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

Parent report of immediate reaction to common food allergen (at 2 years) · infants

Skin care intervention showed no clear difference in parent report of immediate reaction to common food allergen (at 2… compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

Allergic sensitisation to a food allergen (at 1 to 3 years) · infants

Skin care intervention showed no clear difference in allergic sensitisation to a food allergen (at 1 to 3 years) compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Angular cheilitis (WHO clinical stage 2) · Children or adolescents

No significant difference in angular cheilitis prevalence between CLWH and healthy controls (pooled OR 1.95, 95% CI 0.16 to 23.65).

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Oral candidiasis (WHO clinical stage 3) · Children or adolescents

CLWH on ART had markedly higher prevalence of oral candidiasis than healthy controls (pooled OR 16.94, 95% CI 5.06 to 56.70).

1 finding from 1 review

CBT vs alternative treatment

Adverse events · People aged 12 years and over with painful TMD lasting 3 months or longer
1 finding from 1 review
  • SoF: 3 studies reported minor adverse events in the control group; 1 study reported minor adverse events in psychological therapy group; 1 study reported that there were no adverse events. Results: NCT00066937 minor…
    5 studies
    Very low

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Linear gingival erythema (WHO clinical stage 2) · Children or adolescents

No difference in linear gingival erythema between groups (pooled OR 1.00, 95% CI 0.06 to 16.19); the lesion was essentially absent in both groups.

1 finding from 1 review

In-office laser therapy (all types combined) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

It is very uncertain whether in-office laser therapy (all types combined) changes changes in intensity of pain (VAS 0 to 10) tested through air blast… compared with placebo (placebo laser or placebo agent) or no treatment (very low certainty).

3 findings from 1 review

Er,Cr:YSGG laser (erbium,chromium:yttrium-scandium-gallium-garnet) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

Er,Cr:YSGG laser (erbium,chromium:yttrium-scandium-gallium-garnet) led to lower changes in intensity of pain (VAS 0 to 10) tested through air blast… compared with placebo (placebo laser or placebo agent) or no treatment; GRADE not reported.

3 findings from 1 review

Nd:YAG laser vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

Nd:YAG laser (neodymium-doped:yttrium-aluminum-garnet) showed no clear difference in changes in intensity of pain (VAS 0 to 10) tested through air blast… compared with placebo (placebo laser or placebo agent) or no treatment; GRADE not reported.

3 findings from 1 review

In-office laser therapy (all types combined) vs Placebo (placebo laser or placebo agent) or no treatment

Adverse events · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation
2 findings from 1 review

Diode laser, visible red (630 nm to 700 nm) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

Diode laser, visible red (630 nm to 700 nm) led to lower changes in intensity of pain (VAS 0 to 10) tested through tactile… compared with placebo (placebo laser or placebo agent) or no treatment; GRADE not reported.

3 findings from 1 review

Diode laser, near infrared (700 nm to 850 nm) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

Diode laser, near infrared (700 nm to 850 nm) led to lower changes in intensity of pain (VAS 0 to 10) tested through air blast… compared with placebo (placebo laser or placebo agent) or no treatment; GRADE not reported.

3 findings from 1 review

Diode laser, near infrared (850 nm to 980 nm) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

Diode laser, near infrared (850 nm to 980 nm) led to lower changes in intensity of pain (VAS 0 to 10) tested through air blast… compared with placebo (placebo laser or placebo agent) or no treatment; GRADE not reported.

2 findings from 1 review