Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

880 questions · 912 findings · 126 reviews · Headline outcomes only

No studies found 143 · 15.7%GRADE not reported 38 · 4.2%Very low 250 · 27.4%Low 253 · 27.7%Moderate 168 · 18.4%High 60 · 6.6%

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Serious neonatal morbidity

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes serious neonatal morbidity (Reported in Miller 2014 as 'composite… compared with cervical cerclage alone (very low certainty).

1 finding from 1 review

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Perinatal loss: all ‐ including miscarriages and stillbirth (Note: data not available for neonatal death)

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes perinatal loss: all ‐ including miscarriages and stillbirth (Note:… compared with cervical cerclage alone (very low certainty).

1 finding from 1 review

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Preterm birth less than 34 weeks' gestation

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes preterm birth < 34 completed weeks of pregnancy compared with cervical cerclage alone (very low certainty).

1 finding from 1 review

Intravenous diclofenac vs placebo

At least 50% reduction in pain · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac may leads to higher number of participants with at least 50% pain relief at 4 hours compared with placebo (low certainty).

2 findings from 1 review

Intravenous diclofenac vs NSAIDs

Number of participants using rescue medication over 4 to 6 hours postinterventions · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

It is very uncertain whether intravenous diclofenac changes number of participants using rescue medication over 4 to 6 hours… compared with another NSAID (very low certainty).

1 finding from 1 review

Intravenous diclofenac vs NSAIDs

Number of participants reporting an adverse event · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants reporting any adverse event compared with another NSAID (low certainty).

1 finding from 1 review

Intravenous diclofenac vs NSAIDs

Number of participants experiencing any serious adverse events · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants experiencing a serious adverse event compared with another NSAID (low certainty).

1 finding from 1 review

Intravenous diclofenac vs placebo

Number of participants using rescue medication over 4 to 6 hours postinterventions · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac may leads to lower number of participants using rescue medication over 4 to 6 hours… compared with placebo (low certainty).

1 finding from 1 review

Intravenous diclofenac vs placebo

Number of participants reporting an adverse event · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants reporting any adverse event compared with placebo (low certainty).

1 finding from 1 review

Intravenous diclofenac vs placebo

Number of participants experiencing any serious adverse events · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries

Intravenous diclofenac showed no clear difference in number of participants experiencing a serious adverse event compared with placebo (low certainty).

1 finding from 1 review

Intravenous diclofenac vs NSAIDs

At least 50% reduction in pain · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries
2 findings from 1 review