Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Fluoride toothpaste 550 ppm (lower concentration) vs Fluoride toothpaste 1000 ppm or more (higher concentration)

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

Fluoride toothpaste 550 ppm (lower concentration) probably leads to lower fluorosis (percentage prevalence in permanent teeth) compared with fluoride toothpaste 1000 ppm (higher concentration) (moderate certainty).

1 finding from 1 review

Used less than half of the brush of fluoride toothpaste vs Used half or more of the brush

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

It is very uncertain whether used less than half of the brush of fluoride toothpaste changes fluorosis (percentage prevalence in permanent teeth) compared with used half or more of the brush (very low certainty).

1 finding from 1 review

Early childhood caries / severe early childhood caries vs Caries-free controls

Change in height-for-age z score · Children aged ≤6 years (early childhood)

The association between baseline caries and declining height-for-age persisted after adjustment (coefficient -0.02); ungraded.

1 finding from 1 review

Early childhood caries / severe early childhood caries vs Caries-free controls

Stunting · Children aged ≤6 years (early childhood)

One Nepalese cross-sectional study found caries severity significantly correlated with chronic malnutrition/stunting (HAZ; p<0.0001), especially in rural children; ungraded, no effect size reported.

3 findings from 1 review

Surgical vs non‐surgical treatment

Complications requiring unplanned return to theatre Subtalar arthrodesis · people aged over 14 years with displaced intra‐articular calcaneal fractures

Surgical showed no clear difference in complications requiring unplanned return to theatre Subtalar… compared with non‐surgical management (low certainty).

1 finding from 1 review

CBT vs alternative treatment

Reduction in pain intensity · People aged 12 years and over with painful TMD lasting 3 months or longer

Cognitive behavioural therapy (CBT) showed no clear difference in pain intensity at treatment completion compared with alternative (active) treatment (e.g. oral splint, medication,… (low certainty).

2 findings from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Kaposi's sarcoma (WHO clinical stage 4) · Children or adolescents

No eligible studies reported Kaposi's sarcoma.

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Dental development / dental age (mineralization chronology) · Children or adolescents

No significant overall difference in dental development between CLWH on ART and healthy controls (three studies, narrative synthesis).

1 finding from 1 review

CBT vs alternative treatment

Mental distress · People aged 12 years and over with painful TMD lasting 3 months or longer

Cognitive behavioural therapy (CBT) may leads to lower psychological distress at follow-up compared with alternative (active) treatment (e.g. oral splint, medication,… (low certainty).

2 findings from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Recurrent oral ulcerations (WHO clinical stage 2) · Children or adolescents

CLWH on ART had significantly higher prevalence of recurrent oral ulcerations than healthy controls (pooled OR 6.83, 95% CI 1.18 to 39.53).

1 finding from 1 review

CBT vs alternative treatment

Additional physical symptoms · People aged 12 years and over with painful TMD lasting 3 months or longer

The review found no eligible studies for this question.

1 finding from 1 review

CBT vs alternative treatment

Disability caused by pain at follow-up · People aged 12 years and over with painful TMD lasting 3 months or longer

Cognitive behavioural therapy (CBT) showed no clear difference in disability caused by pain at treatment completion compared with alternative (active) treatment (e.g. oral splint, medication,… (low certainty).

2 findings from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Acute necrotizing ulcerative gingivitis/periodontitis (WHO clinical stage 3) · Children or adolescents

No eligible studies reported acute necrotizing ulcerative gingivitis/periodontitis.

1 finding from 1 review