Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Summary of findings table ‐ Intraperitoneal local anaesthetic vs control

Proportion discharged as day surgery · people undergoing laparoscopic cholecystectomy.

It is very uncertain whether summary of findings table ‐ Intraperitoneal local anaesthetic changes proportion discharged as day surgery compared with control (very low certainty).

1 finding from 1 review

Suprapubic catheterisation vs intermittent self‐catheterisation

Adverse events (acute complication after surgery)

It is very uncertain whether suprapubic catheterisation changes adverse events (acute complication after surgery) compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Suprapubic catheterisation vs intermittent self‐catheterisation

Urinary tract infection

It is very uncertain whether suprapubic catheterisation changes urinary tract infections in the first month after surgery compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Anti‐IL‐5 mAb (mepolizumab) vs placebo (on top of topical steroids)

Avoidance of surgery ‐ patients still meeting the criteria for surgery At end of · patients with severe chronic rhinosinusitis with nasal polyps

It is very uncertain whether anti‐IL‐5 mAb (mepolizumab) changes avoidance of surgery ‐ patients still meeting the criteria for… compared with placebo (on top of topical steroids) (very low certainty).

1 finding from 1 review

Anti‐IgE mAb (omalizumab) vs placebo (on top of topical steroids)

Avoidance of surgery Nasal polyp score ≤4 (≤ 2 on each side) and an improvement in SNOT‐22 score of ≥ 8.9 points · patients with chronic rhinosinusitis with nasal polyps

Anti‐IgE mAb (omalizumab) may leads to higher avoidance of surgery Nasal polyp score ≤4 (≤ 2 on each side) and an… compared with placebo (on top of topical steroids) (low certainty).

1 finding from 1 review

Anti‐IL‐4Rα mAb (dupilumab) vs placebo (on top of topical steroids)

Avoidance of surgery ‐ number of patients who had surgery as rescue treatment · patients with severe chronic rhinosinusitis with nasal polyps

Anti‐IL‐4Rα mAb (dupilumab) probably leads to lower avoidance of surgery ‐ number of patients who had surgery as rescue… compared with placebo (on top of topical steroids) (moderate certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Urinary continence 3 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in urinary continence 3 months after surgery MCID: 5% absolute difference compared with no posterior reconstruction (low certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Urinary continence 6 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in urinary continence 6 months after surgery MCID: 5% absolute difference compared with no posterior reconstruction (moderate certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Urinary continence 12 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in urinary continence 12 months after surgery MCID: 5% absolute… compared with no posterior reconstruction (low certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Potency 12 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

It is very uncertain whether posterior reconstruction changes potency recovery 12 months after surgery MCID: 5% absolute difference compared with no posterior reconstruction (very low certainty).

1 finding from 1 review