What do systematic reviews say?

Herbal preparations vs medication

• Herbal preparations for uterine fibroids 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Herbal preparations vs medication

• Herbal preparations for uterine fibroids 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Acupuncture vs medication

• Acupuncture for treating fibromyalgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 38 participants
  Low

Acupuncture vs medication

The review found no eligible studies for this question.

• Acupuncture for treating fibromyalgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs medication

The review found no eligible studies for this question.

• Acupuncture for treating fibromyalgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs medication

The review found no eligible studies for this question.

• Acupuncture for treating fibromyalgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs medication

The review found no eligible studies for this question.

• Acupuncture for treating fibromyalgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs medication

The review found no eligible studies for this question.

• Acupuncture for treating fibromyalgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs medication

• Acupuncture for treating fibromyalgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 38 participants
  Low

Powered toothbrush (any mode of action) vs Manual toothbrush

Powered toothbrush showed no clear difference in stimulated whole saliva (SWS) compared with manual toothbrush; GRADE not reported.

• Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes

  5 minutes after brushing
  MD -0.13 [-1.92, 1.66]
  1 study
  GRADE not reported

Powered toothbrush (any mode of action) vs Manual toothbrush

• Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes
  Papas 2006 used a VAS to measure mouth dryness but did not report dry mouth outcome data
  1 study
  GRADE not reported

Second generation antidepressant vs placebo medication

• Newer generation antidepressants for depressive disorders in children and adolescents 2012 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Second generation antidepressant vs placebo medication

• Newer generation antidepressants for depressive disorders in children and adolescents 2012 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Second generation antidepressant vs placebo medication

Second generation antidepressant probably leads to higher remission or response (as defined in trial) compared with placebo (by medication) (moderate certainty).

• Newer generation antidepressants for depressive disorders in children and adolescents 2012 · Cochrane Headline outcomes only
  RR 1.18 [1.08, 1.28]
  16 studies · 2924 participants
  Moderate

Second generation antidepressant vs placebo medication

Second generation antidepressant may leads to higher suicide‐related outcome compared with placebo (by medication) (low certainty).

• Newer generation antidepressants for depressive disorders in children and adolescents 2012 · Cochrane Headline outcomes only
  RR 1.58 [1.02, 2.45]
  17 studies · 3229 participants
  Low

Second generation antidepressant vs placebo medication

• Newer generation antidepressants for depressive disorders in children and adolescents 2012 · Cochrane Headline outcomes only
  no estimate extracted
  14 studies · 2490 participants
  Low

Acupuncture vs medication

Acupuncture may leads to higher symptom severity (dichotomous outcome) Dichotomous measure of… compared with pharmaceutical medications (low certainty).

• Acupuncture for treatment of irritable bowel syndrome 2012 · Cochrane Headline outcomes only
  RR 1.28 [1.12, 1.45]
  5 studies · 449 participants
  Low

Carboxymethylcellulose (CMC) spray vs Placebo (spray base without CMC / water)

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Donatsky 1982 (crossover, n=15, Sjogren's syndrome): CMC spray had a similar effect on oral dryness to the spray base, but was more effective than water. Paired crossover data not presented; effect size not estimable.
  1 study · 15 participants
  GRADE not reported

Reservoir biteguard device releasing a saliva substitute (with KY jelly + Saliva Orthana) vs Biteguard without reservoir (with KY jelly + Saliva Orthana)

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  More in the reservoir group experienced relief of an oral impact and fewer a new impact (OIDP), but no difference in the total impact score between groups.
  1 study · 86 participants
  GRADE not reported

Saliva stimulant lozenge (sorbitol, Sorbee) vs Saliva substitute spray

Saliva stimulant lozenge (sorbitol, Sorbee) led to lower patient preference compared with saliva substitute spray (MouthKote); GRADE not reported.

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Stewart 1998: no statistically significant difference in patient preference between lozenge and spray (Analysis 2.3).
  1 study · 80 participants
  GRADE not reported