Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,640 questions · 2,709 findings · 446 reviews

No studies found 593 · 21.9%GRADE not reported 241 · 8.9%Very low 538 · 19.9%Low 706 · 26.1%Moderate 516 · 19%High 115 · 4.2%

Group B cognitive behavioural therapy: cognitive behavioural therapy + supportive therapy vs supportive therapy

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Long‐term (events) compared with supportive therapy (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy (specific preventive intervention) + needs‐based intervention + risperidone vs needs‐based intervention

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Endpoint data (events)… compared with needs‐based intervention (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy (specific preventive intervention) + needs‐based intervention + risperidone vs needs‐based intervention

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes satisfaction with treatment: leaving the study early (events)… compared with needs‐based intervention (very low certainty).

1 finding from 1 review

Cognitive training vs active control

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: cognitive training changes satisfaction with treatment: leaving the study early Endpoint data… compared with active control (tablet games) (very low certainty).

1 finding from 1 review

Group C other: family treatment vs enhanced care

Prodromal symptoms: transition to psychosis FACT Long‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: family treatment changes prodromal symptoms: transition to psychosis FACT Long‐term compared with enhanced care (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids may leads to lower prodromal symptoms: transition to psychosis Long‐term (events) compared with placebo (low certainty).

1 finding from 1 review

Group C other: family treatment vs enhanced care

Satisfaction with treatment: leaving the study early FACT Long‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: family treatment changes satisfaction with treatment: leaving the study early FACT Long‐term compared with enhanced care (very low certainty).

1 finding from 1 review

Group C other: integrated treatment vs usual care

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group C other: integrated treatment changes prodromal symptoms: transition to psychosis Endpoint data (events)… compared with standard treatment (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Global state: antipsychotic prescription Long‐term (events) · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids may leads to lower global state: antipsychotic prescription Long‐term (events) compared with placebo (low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Major complications · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes major complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Mortality within the longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes all‐cause mortality (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Non‐surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes non‐surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review