Findings

What do systematic reviews say?

1,268 questions · 1,343 findings · 197 reviews

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No studies found 317 · 23.6%GRADE not reported 189 · 14.1%Very low 356 · 26.5%Low 271 · 20.2%Moderate 173 · 12.9%High 37 · 2.8%

Laparoscopic vs open appendectomy

Pain (unpleasantness/intensity/palpation) · patients with suspected appendicitis

1 finding from 1 review

Laparoscopic versus open surgery for suspected appendicitis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 61 participants
Low

Laparoscopic vs open appendectomy

Surgical complications ‐ wound infection · patients with suspected appendicitis

Laparoscopic probably leads to lower wound infections (rate) compared with open appendectomy (moderate certainty).

1 finding from 1 review

Laparoscopic versus open surgery for suspected appendicitis 2018 · Cochrane Headline outcomes only
Peto OR 0.25 [0.15, 0.42]
10 studies · 1245 participants
Moderate

Summary of findings table ‐ Platelet transfusion vs no platelet transfusion

Major procedure‐related bleeding · thrombocytopenia

1 finding from 1 review

Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in… 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 150 participants
Very low

Summary of findings table ‐ Platelet transfusion vs no platelet transfusion

All‐cause mortality up to 30 days after the procedure · thrombocytopenia

The review found no eligible studies for this question.

1 finding from 1 review

Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Platelet transfusion vs no platelet transfusion

Transfusion‐related complications within 24 hours of the procedure · thrombocytopenia

The review found no eligible studies for this question.

1 finding from 1 review

Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Platelet transfusion vs no platelet transfusion

Procedure‐related (lumbar puncture or epidural anaesthetic) complications within 7 days of the procedure · thrombocytopenia

1 finding from 1 review

Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 21 participants
Very low

Summary of findings table ‐ Platelet transfusion vs no platelet transfusion

Quality of life (as defined by the individual studies) · thrombocytopenia

The review found no eligible studies for this question.

1 finding from 1 review

Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs usual care

Complete wound healing · open fracture wounds

NPWT 125 mmHg showed no clear difference in complete wound healing compared with standard care (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 1.01 [0.81, 1.27]
1 study · 460 participants
Moderate

NPWT 125 mmHg vs usual care

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · other open traumatic wounds

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 51 participants
Low

NPWT 75 mmHg vs usual care

Complete wound healing · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 75 mmHg vs usual care

Wound infection · other open traumatic wounds

It is very uncertain whether NPWT 75 mmHg changes wound infection compared with standard care (very low certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 0.44 [0.17, 1.1]
1 study · 463 participants
Very low

NPWT 75 mmHg vs usual care

Adverse events · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 75 mmHg vs usual care

Time to closure or coverage surgery · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 75 mmHg vs usual care

Pain · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs NPWT 75 mmHg

Complete wound healing · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs NPWT 75 mmHg

Wound infection · other open traumatic wounds

It is very uncertain whether NPWT 125 mmHg changes wound infection compared with NPWT 75 mmHg (very low certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 1.04 [0.31, 3.51]
1 study · 251 participants
Very low

NPWT 125 mmHg vs NPWT 75 mmHg

Adverse events · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs NPWT 75 mmHg

Time to closure or coverage surgery · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs usual care

Wound infection · open fracture wounds

It is very uncertain whether NPWT 125 mmHg changes wound infection compared with standard care (very low certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 0.48 [0.2, 1.13]
4 studies · 596 participants
Very low

NPWT 125 mmHg vs NPWT 75 mmHg

Pain · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found